The decapeptide CMS001 enhances swimming endurance in mice

Wang, Li; Zhang, Huali; Lü, Rong; Zhou, Yanjiao; Ma, Rui; Lv, Junqiang; Li, Xiaolei; Chen, Lijuan; Yao, Zhi

doi:10.1016/j.peptides.2008.03.004

Cited by 122 publications

(116 citation statements)

References 18 publications

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“…Most active compounds in exercise supplements, such as peptides (8), polysaccharides (9-11), flavonoids (12), and terpenoids (13), originate from herbal sources. Recently, compounds from animal sources, such as antioxidant peptides from grass carp Ctenopharyngodon idellus (14) and pig spleen (15), have been identified as enhancers of swimming endurance. To date, few studies have examined compounds from aquatic organisms as potential exercise performance enhancers.…”

Section: Introductionmentioning

confidence: 99%

Hot Water Extract of Leather Carp (Cyprinus carpio nudus) Improves Exercise Performance in Mice

Lee

Harwanto

Park

et al. 2015

JFN

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ABSTRACT:The hot water extract of leather carp (Cyprinus carpio nudus) has been used as a nourishing tonic soup and as an aid for recovery from physical fatigue. In this study, we investigated the effect of leather carp extract on exercise performance in mice. Swimming endurance and forelimb grip strength were assessed following oral administration of the extract (once per day for 7 days) at a dose of 0.5 mg/10 L/g body weight. After 7 days, mice given the leather carp extract had significantly greater swimming endurance [105±18 s (P＜0.05); 52% longer than day 0] and forelimb grip strength [1.18±0.05 Newton (P＜0.01); 17% greater than day 0]. The extract increased muscle mass, but had little effect on body weight. Following the swimming exercise, blood glucose, glutathione peroxidase, and superoxide dismutase levels in extract-fed mice were significantly higher (145%, 131%, and 106%, respectively) than in the saline control group. Blood levels of high-density lipoprotein cholesterol were also significantly increased (128%) in mice given the extract compared to the controls. These results suggest that leather carp extract can improve physical exercise performance and prevent oxidative stress caused by exhaustive workouts.

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Section: Introductionmentioning

confidence: 99%

Hot Water Extract of Leather Carp (Cyprinus carpio nudus) Improves Exercise Performance in Mice

Lee

Harwanto

Park

et al. 2015

JFN

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Viral and bacterial, infections, psychosocial and physical stressors can be important factors for fatigue symptoms [7,9,[21][22][23], it can also result from exhaustion of energy sources such as glucose and glycogen due to intense exercise [24][25][26]. Over accumulation of serum lactic acid and blood urea nitrogen will also result in metabolic disorders leading to fatigue [25,27]. Moreover intense exercise can cause accumulation of reactive free radicals which will lead the body in a state of oxidative stress and bring injury to the body by attacking large molecules and cell organs leading to physical fatigue [24,25,28,29].…”

Section: Introductionmentioning

confidence: 99%

“…Over accumulation of serum lactic acid and blood urea nitrogen will also result in metabolic disorders leading to fatigue [25,27]. Moreover intense exercise can cause accumulation of reactive free radicals which will lead the body in a state of oxidative stress and bring injury to the body by attacking large molecules and cell organs leading to physical fatigue [24,25,28,29].…”

Section: Introductionmentioning

confidence: 99%

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Mechanism of Mitochondrial Dysfunction during Chronic Fatigue

Muluye¹,

Bian²

2017

Int J Phys Med Rehabil

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A clinically defined condition characterized by persistent, severe, disabling fatigue lasting more than six months that is not reversed by sleep is regarded as chronic fatigue (CF). Fatigue is a complex phenomenon determined by several factors, including psychological health but at the biochemical level fatigue is related to the metabolic energy available to tissues and cells, mainly through mitochondrial respiration. Fatigue is the most common symptom of poorly functioning mitochondria. therefore dysfunction of these organelles may be the cause of the fatigue seen in CF. There is a great progress in the molecular understanding of mitochondrial disorder but the relation of mitochondrial dysfunction with CF and the underlying mechanism is not identified well in addition treatment of fatigue is still inadequate. In this review we try to summarize the relation between CF with mitochondrial dysfunction and determine the underline mechanism.

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“…Considering fatigue is related to many research methods, the mechanism of fatigue is still controversial. Currently, the major theories regarding the mechanism of exercise fatigue include clogging theory, exhaustion theory, homeostasis disturbance theory, radical theory, protective inhibition theory, disorder of metabolic ion theory, and mutation theory (Harman 1956;Pedersen et al 2004;Sugino et al 2007;Wang et al 2008;You et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and anti-exercise-fatigue effect of highly denatured soybean meal hydrolysate prepared using neutrase

2013

J Food Sci Technol

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Highly denatured soybean meal is a by-product of soybean oil extraction obtained through high-temperature desolventization. High-temperature treatment can result in soybean protein denaturation. Compare with ordinary soybean meal, the protein structure of highly denatured soybean meal has changed. Highly denatured soybean meal was pretreated with thermal treatment or ultrasonication, and then hydrolyzed with neutrase. The ultrasonicated hydrolysate exhibited better antioxidant activity than the thermally treated hydrolysate. The ultrasonication increased 1,1-diphenyl-2-pycryl hydrazyl (DPPH) radical scavenging activity by 8.31 % and reduction capacity by 10.19 %. The highly denatured soybean meal hydrolysate ultrasonicated at 400 W exhibited the highest antioxidant activity. The DPPH radical scavenging activity was 56.22 % and reduction capacity was 0.717. The ultrasonicated hydrolysate at 400 W was fractionated using ultrafiltration into three fractions: I (>10 kDa), II (5 kDa to 10 kDa), and III (<5 kDa). The in vitro antioxidant activity and others in vivo anti-exercise-fatigue effect of the three fractions (I, II, and III) were determined. Fraction III exhibited the highest DPPH radical scavenging activity and reduction capacity, improved the hemoglobin and hepatic glycogen content and reduced blood urea nitrogen and blood lactic acid. Fraction III improved the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) and reduced the malonaldehyde (MDA) content in mouse livers. Therefore, the highly denatured soybean meal hydrolysate has an anti-oxidative effect and it significantly alleviates exercisefatigue in mice. Amino acids of hydrolysate were determined.Results showed that the antioxidant activity and anti-exercisefatigue effect were related to the amino acid compositions.

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The decapeptide CMS001 enhances swimming endurance in mice

Cited by 122 publications

References 18 publications

Hot Water Extract of Leather Carp (Cyprinus carpio nudus) Improves Exercise Performance in Mice

Hot Water Extract of Leather Carp (Cyprinus carpio nudus) Improves Exercise Performance in Mice

Mechanism of Mitochondrial Dysfunction during Chronic Fatigue

Antioxidant activity and anti-exercise-fatigue effect of highly denatured soybean meal hydrolysate prepared using neutrase

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