The deciduomal reaction in the rhesus monkey (Macaca mulatta). I. The epithelial proliferation

Rossman, Isadore

doi:10.1002/aja.1000660206

Cited by 55 publications

(18 citation statements)

References 32 publications

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“…Both of these can be induced by traumatization (Rossman, 1940) or injection of oil into the uterus at the appropriate time (Marston et at., 1971;Beck, 1974). The cells later become necrotic, as in normal pregnancy, indicating that the epithelial response is an intrinsic part of the maternal pregnancy reaction and requires only the trophoblast, or an artificial stimulus, for its initiation.…”

Section: Epithelial Changesmentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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Implantation involves the attachment of the blastocyst to the wall of the uterus with, in some cases, the embedding of the entire ovum in the uterine wall. Associated with it are very profound and characteristic changes in the endometrium both during preparation for implantation and following attachment of the blastocyst. In this chapter, the uterine changes that take place during preparation will be considered first and then the changes during the process of implantation. The former occur regularly and frequently throughout the life of most female mammals, whereas the latter are rarer events, especially in women. This division of the subject is also convenient for the consideration of the control mechanism involved. Whereas the preparative changes are largely directed by the varying levels of the hormones secreted by the ovary, once the implantation process has been initiated hormones playa largely permissive role.There is considerable species variation in the reaction of the uterus in preparation for and during implantation. De Feo (1967) reviewed this subject very thoroughly in the first edition of this book. The great majority of research investigations have been carried out on laboratory rodents, with very little on primates or the larger domestic animals. It follows therefore that any general account of implantation will lean heavily on information acquired from laboratory animals. Although one would like to have a much more general coverage, one cannot escape the reality that information acquired from many experiments on large numbers of laboratory animals provides a sound foundation on which to build. Information from primates or wild mammals will always tend to be fragmentary because of the difficulty of obtaining large numbers of specimens. Anyone who has worked with rats or mice knows how easy it is to be misled by the results from two or three animals. The only sensible course therefore is to get as

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Section: Epithelial Changesmentioning

confidence: 99%

The Implantation Reaction

Finn

1977

Biology of the Uterus

171

121

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“…Several groups have shown that in the rhesus monkey plaque formation is an invariable endometrial response of the progestational uterus to trauma (Rossman, 1940;Marston, Kelly & Eckstein, 1971;Ghosh & Sengupta, 1989). The ultrastructural and temporal peculiarities of these cellular changes have not been investigated previously, however.…”

Section: Discussionmentioning

confidence: 99%

Endometrial response to deciduogenic stimulus in ovariectomized rhesus monkeys treated with oestrogen and progesterone: an ultrastructural study

Sengupta

Given

Talwar

et al. 1990

Journal of Endocrinology

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The present work continues our aim of establishing an experimental model to study the decidual cell reaction to an artificial deciduogenic stimulus in the long-term ovariectomized rhesus monkey treated with oestrogen followed by progesterone. The fine structural details of decidual, granular and plaque cells, which constituted the endometrial cellular response to the deciduogenic stimulation in the present study, revealed striking similarities with those reportedly present in an endometrial response to blastocyst implantation in the rhesus monkey. Plaque epithelia showed a significant degree of hypertrophy, hyperplasia and differentiation followed by a steady degeneration by day 32 (equivalent to day 16 after trauma) of treatment. The plaque cells were shown to contain numerous regular-shaped mitochondria, polyribosomes and large amounts of rough endoplasmic reticulum (RER) in their cytoplasm and were characteristically arranged in clusters or acini formation surrounded by discrete basal laminae. As early as day 28 of treatment, the initiation of stromal decidual cell transformation was noted and, by day 48, a sizeable pool of decidual cells was found. The decidual cells had rounded nuclei and elaborate arrangements of interconnected cisternae of RER which were often moderately dilated and filled with amorphous, electron-dense material. Granular cells were characterized by eccentrically located nuclei and numerous membrane-bound, electron-dense granules in their cytoplasm and were found in increasing numbers in the stroma around decidual cells, blood vessels and glandular epithelia.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…This tissue was transferred to vials containing Rossman's fixative (Rossman, 1940) that had been cooled overnight at -80°C. Vials were stored at -80°C for a minimum of 2 weeks for freeze substitution according to the Peyrot modification of the Lison technique for glycogen (Pearse, 1960).…”

Section: Histochemistrymentioning

confidence: 99%

Effects of compound 48/80 on hepatic glycogen and glucose‐6‐phosphatase early in the diurnal cycle of the rat

Dimlich

Cardell

1984

Am. J. Anat.

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The amount and distribution of glycogen as well as the activity of glucose-6-phosphatase (G-6-Pase) in the livers of rats were analyzed by biochemical and/or histochemical techniques. During the first 5 hr of the light cycle, livers of rats were sampled prior to and 30 min following an injection of compound 48/80 or Ringer's solution. Glycogen decreased significantly in response to sampling; however, treatment with compound 48/80 provoked an additional significant decrease in hepatic glycogen. These differences occurred irrespective of the time during the 5 hr that this was studied. The livers of the majority of the rats treated with compound 48/80 displayed a periportal distribution of glycogen, while those treated with Ringer's showed a more uniform pattern. Hepatic G-6-Pase activity was unchanged in either the Ringer's or compound 48/80 treated rats. These results indicated that (1) the significant glycogenolytic response occurs independently of the amount of glycogen present, (2) G-6-Pase activity is not affected within 30 min following the stimulation of glycogenolysis, (3) variation in glycogen patterns during depletion depends on the nature of the stimulus and/or degree of response, and (4) the amount of glycogen available for release is limited.

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The deciduomal reaction in the rhesus monkey (Macaca mulatta). I. The epithelial proliferation

Cited by 55 publications

References 32 publications

The Implantation Reaction

The Implantation Reaction

Endometrial response to deciduogenic stimulus in ovariectomized rhesus monkeys treated with oestrogen and progesterone: an ultrastructural study

Effects of compound 48/80 on hepatic glycogen and glucose‐6‐phosphatase early in the diurnal cycle of the rat

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