The Decline in Hip Bone Density after Gastric Bypass Surgery Is Associated with Extent of Weight Loss

Fleischer, Jessica; Stein, Emily; Bessler, Marc; Badia, Miquel; Restuccia, Nancy; Olivero-Rivera, Lorraine; McMahon, Donald J.; Silverberg, Shonni J.

doi:10.1210/jc.2008-0481

Cited by 260 publications

(297 citation statements)

References 36 publications

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“…Fleischer and cols. (18) reported that the extension of weight loss is directly associated with the intensity of the reduction in BMD at all sites.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of hyperparathyroidism may reach 58% in patients after RYBG (14)(15)18). Furthermore, patients submitted to bariatric surgery may present chronic magnesium depletions which also leads to a blunt in PTH secretion, osteoporosis and vitamin D deficiency (20).…”

Section: Discussionmentioning

confidence: 99%

“…The 24-hour urinary calcium presents a significant reduction in operated patients (17)(18) even with adequate calcium replacement, which may be associated with a reduced intestinal absorption and, concomitantly, an increased need for a higher daily intake of calcium.…”

Section: Discussionmentioning

confidence: 99%

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Bariatric surgery and bone metabolism: a systematic review

Viégas

Vasconcelos

Neves

et al. 2010

Arq Bras Endocrinol Metab

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SUMMARYFew studies have demonstrated the risk of metabolic bone disease and a reduction in bone mineral density (BMD) after bariatric surgery. A systematic review was conducted of case-control and cohort studies with the aim of evaluating the relationship between bariatric surgery and bone metabolism. The search was undertaken in MedLine, covering the period from January 1997 to August 2009, using the keywords: "bariatric surgery" AND "osteoporosis" , "fracture" , "bone diseases" , "metabolic" . Six studies were included, comprising four cohort and two casecontrol studies. Three studies evaluated bone metabolism and BMD, and the other evaluated bone metabolism only. Based on this review, bariatric surgery is associated with alterations in bone metabolism, loss of bone mass and an increased risk of fracture. However, the maximum evaluation period covered by these studies was two years after surgery, hence the need to undertake further studies of longer duration in order to achieve a more thorough understanding of this association. Arq Bras Endocrinol Metab. 2010;54(2):158-63 Keywords Osteoporosis; fracture; bariatric surgery; bone diseases SUMÁRIO Alguns estudos têm demonstrado aumento do risco de doença osteometabólica e redução de densidade mineral óssea (DMO) após a cirurgia bariátrica. Realizou-se uma revisão sistemática de estudos de caso-controle e coorte com o objetivo de avaliar a relação entre cirurgia bariátri-ca e o metabolismo ósseo. A procura foi realizada na MedLine de janeiro 1997 a agosto 2009, utilizando os descritores: "bariatric surgery" e "osteoporosis" , "fracture" , "bone diseases" , "metabolic" . Foram incluídos seis estudos, sendo quatro coortes e dois casos-controle. Três desses estudos avaliaram metabolismo ósseo e DMO e os demais avaliaram apenas o metabolismo ósseo. Com base nesta revisão, a cirurgia bariátrica está associada com alterações no metabolismo ósseo, perda de massa óssea e aumento no risco de fraturas. Entretanto, os estudos tiveram acompanhamento máximo de dois anos após a cirurgia, havendo necessidade de estudos de maior seguimento para melhor conhecimento dessa associação. Arq Bras Endocrinol Metab. 2010;54(2):158-63

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“…Fleischer and cols. (18) reported that the extension of weight loss is directly associated with the intensity of the reduction in BMD at all sites.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bariatric surgery and bone metabolism: a systematic review

Viégas

Vasconcelos

Neves

et al. 2010

Arq Bras Endocrinol Metab

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“…[16][17][18] In addition, the extent of bone loss varies with each study and none have been carried out in a sufficient number of patients to allow a firm conclusion. [19][20][21] Thus, the aim of this review is to summarize the current state of knowledge regarding the relationship between bariatric operations and bone metabolism, to understand the specific mechanisms of action and to suggest further research studies.…”

Section: Introductionmentioning

confidence: 99%

Bariatric surgery and bone disease: from clinical perspective to molecular insights

et al. 2012

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“…Serum calcium, however, is an unreliable marker, as although total body calcium maybe reduced, serum calcium is often maintained by the action of PTH. Bone turnover can also be measured using markers such as osteocalcin, which in surgically induced weight loss is significantly raised [27,28].…”

Section: Methods For Assessing Metabolic Bone Changesmentioning

confidence: 99%

Metabolic Bone Disease and Bariatric Surgery

Sanghera¹

2013

J Gastrointest Dig Syst

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The prevalence of obesity is increasing worldwide and the past decade has witnessed an exponential rise in the number of bariatric operations performed. As a consequence, it is expected that an increasing number of patients are likely to be at risk of long term complications that may not manifest until years or decades later. Several studies have investigated the short and long-term complications of bariatric surgery but there is little available data on the longterm consequences on bone metabolism and the consequences of this after bariatric surgery. This paper reviews the current literature for further information on this clinically relevant issue.

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The Decline in Hip Bone Density after Gastric Bypass Surgery Is Associated with Extent of Weight Loss

Cited by 260 publications

References 36 publications

Bariatric surgery and bone metabolism: a systematic review

Bariatric surgery and bone metabolism: a systematic review

Bariatric surgery and bone disease: from clinical perspective to molecular insights

Metabolic Bone Disease and Bariatric Surgery

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