The decline of the incidence of meningococcal disease in Barcelona between 1988 and 2015: The influence of the vaccine against serogroup C

Manzanares-Laya, Sandra; Parés‐Badell, Oleguer; Gorrindo, Pilar; Simón, Pere; Ros, Miriam; Andrés, Anna de; Segura, N. López; Sanagustín, Sonia Brió; Vilella, Anna; Liria, C. Rodrigo Gonzalo de; Orcau, Àngels; Caylà, Joan A.

doi:10.1016/j.medcle.2018.09.008

Cited by 1 publication

(2 citation statements)

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“…Rates of hospitalization and mortality decreased in the period studied, especially from 2000 with the introduction of the conjugated vaccine for serogroup C as observed in Spain [ 11 ] and nearby countries [ 23 , 25 ]. In the present study, we observed this global decrease, which lowered the MI rate from 4.24 in 1997 to 0.79 in 2018.…”

Section: Discussionmentioning

confidence: 99%

“…Serogroups B and C are traditionally the most frequent causes of disease in Western countries, with an important increase in serogroups W and Y occurring in the last decade [ 10 ]. However, serogroup C disease has decreased dramatically in Spain due to the incorporation of serogroup C vaccines into routine childhood vaccination schedules [ 11 ]. Meningococcal serogroups C and W account for substantial proportions of meningococcal disease in most of Africa and Latin America.…”

Section: Introductionmentioning

confidence: 99%

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Hospitalizations related to meningococcal infection in Spain from 1997 to 2018

et al. 2021

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Background Baseline hospitalization, mortality, and in-hospital fatality rates for meningococcal infection are required to evaluate preventive interventions, such as the inclusion of the conjugated quadrivalent meningococcal vaccine and serogroup B based protein vaccines. Methods All meningococcal infection–related hospitalizations in any diagnostic position in Spain from 1st January 1997 through 31st December 2018 were analysed. The annual hospitalization rate, mortality rate and case-fatality rate were calculated. Results The average hospitalization rate for meningococcal infection was 1.64 (95% CI 1.61 to 1.66) hospitalizations per 100,000 inhabitants during the study period and significantly decreased from 1997 to 2018. Hospitalizations for meningococcal infection decreased significantly with age and were concentrated in children under 5 years of age (46%). The hospitalization rates reached 29 per 100,000 and 24 per 100,000 children under 1 and 2 years of age, respectively. The in-hospital case-fatality rate was 7.45% (95% CI 7.03 to 7.86). Thirty percent of the deaths occurred in children under 5 years of age, and more than half occurred in adults. The case fatality rate increased significantly with age (p < 0.001). Conclusion It is necessary to maintain epidemiological surveillance of meningococcal infection to determine the main circulating serogroups involved, track their evolution, and evaluate preventive measures whose effectiveness must be assessed in all age groups.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%