The decrease of serum MMP-2 activity corresponds to alcoholic cirrhosis stage

Mądro, Agnieszka; Czechowska, Grażyna; Słomka, Maria; Celiński, Krzysztof; Szymonik-Lesiuk, S.; Kurzepa, Jacek

doi:10.1016/j.alcohol.2011.07.008

Cited by 7 publications

(4 citation statements)

References 8 publications

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“…Our results agree with previous studies indicating that chronic liver damage usually favors fibrogenesis over fibrolysis (Park et al, 2010[ 41 ]). In agreement with our results, the work done by Madro et al (2012[ 32 ]) showed a significant decrease of serum MMP2 activity in stages B and C of alcoholic cirrhosis patients rather than early stages. HE is a serious complication of a fibrotic liver.…”

Section: Discussionsupporting

confidence: 94%

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

Elberry

Amin

Esmail

et al. 2016

EXCLI Journal; 15:Doc652; ISSN 1611-2156

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Section: Discussionsupporting

confidence: 94%

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

Elberry

Amin

Esmail

et al. 2016

EXCLI Journal; 15:Doc652; ISSN 1611-2156

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“…Others have shown that MMP-2 is significantly elevated when proteinuria is given [17] (creatinine showed a positive correlation to MMP-2 concentrations in univariate analysis). In our cohort, the level of ASAT was positively correlated with an increase in MMP-2 concentrations; some authors have shown an association with liver cirrhosis [18] . Unadjusted MMP-2 is decreased in the SC, irrespective of etiology; therefore, higher than expected levels of MMP-2 in patients with stroke may -at least in parts -be driven by concomitant kidney and liver disease.…”

Section: Effects Of Subject-specific and Baseline Parameters Without mentioning

confidence: 75%

True Effects or Bias? MMP-2 and MMP-9 Serum Concentrations after Acute Stroke

Kreisel

Stroick²,

Griebe

et al. 2016

Cerebrovasc Dis

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Background: Average serum matrix metalloproteinase (MMP) concentrations in patients with acute stroke have shown to be varying across studies. Possibly, next to true effects, other factors may influence MMP levels. The aim of this study was to investigate the dynamics of these enzymes in repeated measurements in the acute post-stroke period, in respect to different stroke etiologies, and highlight potential sources for variability. Methods: Serum in 233 patients with acute ischemic or hemorrhagic stroke (stroke cohort; SC) was ascertained within 24 h after onset and then 1, 3 and 7 days thereafter. One hundred five controls (control cohort; Co) were recruited. Multi-variable adjustment was carried out using salient extraneous covariates including stroke etiology, clinical severity and lesion size next to a set of routine laboratory parameters. Results: Unadjusted SC MMP-2 concentrations are significantly lower (SC 165.4, 95% CI 158.5-172.4; Co 203.7 ng/ml, 95% CI 190.7-216.5; p < 0.001) and MMP-9 concentrations significantly higher than in controls (SC 608.5 ng/ml, 95% CI 555.3-661.8; Co 475.6 ng/ml, 95% CI 413.6-537.6; p < 0.001). Adjustment mitigates associations between MMP concentrations and stroke etiology, clinical severity, lesion size or differences in temporal profile shown present without adjustment. Salient covariates absorb much of the effect: age, leukocyte count and albumin concentrations are associated significantly with MMP-2 concentrations; only leukocyte count is significantly associated with MMP-9. Conclusions: Concentrations of MMP-2 and MMP-9 in serum in humans measured after acute stroke are potentially influenced by extraneous covariates rather than being directly associated with characteristics of the underlying stroke.

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“…The MMP-9 activity is low in cirrhotic patients compared to normal controls and decreases over time as chronic liver disease progresses to liver cirrhosis 20-22. The reason why the MMP-9 activity is low in cirrhotic patients compared to healthy controls is unclear.…”

Section: Discussionmentioning

confidence: 99%

Increased Serum Activity of Matrix Metalloproteinase-9 in Patients with Acute Variceal Bleeding

Kwon¹,

Jung²,

Bae³

et al. 2012

Gut Liver

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Background/AimsMatrix metalloproteinases (MMP)-2 and -9 can degrade essential components of vascular integrity. The aim of this study was to investigate the association between those MMPs and variceal bleeding (VB).MethodsFifteen controls, 12 patients with acute ulcer bleeding (UB) group, 37 patients with varix (V group), and 35 patients with acute VB group were enrolled. Serum was obtained to measure MMP-2 and -9 activity by zymogram protease assays.ResultsThe activity levels of these compounds were compared with the controls' median value. The median MMP-9 activity was 1.0 in controls, 1.05 in the UB group, 0.43 in the V group, and 0.96 in the VB group. The level of MMP-9 activity was higher in the VB group than in the V group (p<0.001). In the VB group, there was a signifi cant decrease in MMP-9 activity over time after bleeding (p<0.001). The median MMP-2 activity level was 1.0 in controls, 1.01 in the UB group, 1.50 in the V group, and 1.55 in the VB group. The level of MMP-2 activity was similar in the VB and V groups.ConclusionsThe level of MMP-9 activity increased in association with VB. The role of MMP-9 in the pathogenesis of VB should be verified.

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The decrease of serum MMP-2 activity corresponds to alcoholic cirrhosis stage

Cited by 7 publications

References 8 publications

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis

True Effects or Bias? MMP-2 and MMP-9 Serum Concentrations after Acute Stroke

Increased Serum Activity of Matrix Metalloproteinase-9 in Patients with Acute Variceal Bleeding

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