The Ded1/DDX3 subfamily of DEAD-box RNA helicases

Sharma, Deepak; Jankowsky, Eckhard

doi:10.3109/10409238.2014.931339

Cited by 158 publications

(217 citation statements)

References 165 publications

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“…Because Ded1 is an active helicase by itself, it is an excellent model for biochemical studies of RNA helicase activities (Iost et al 1999;Yang and Jankowsky 2005). A recent comprehensive review of Ded1 provides a detailed summary of RNA helicase activities and wider roles of Ded1 and its homologs (Sharma and Jankowsky 2014).…”

Section: Mrna Recruitment Of the 43s Picmentioning

confidence: 99%

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

2016

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In this review, we provide an overview of protein synthesis in the yeast Saccharomyces cerevisiae. The mechanism of protein synthesis is well conserved between yeast and other eukaryotes, and molecular genetic studies in budding yeast have provided critical insights into the fundamental process of translation as well as its regulation. The review focuses on the initiation and elongation phases of protein synthesis with descriptions of the roles of translation initiation and elongation factors that assist the ribosome in binding the messenger RNA (mRNA), selecting the start codon, and synthesizing the polypeptide. We also examine mechanisms of translational control highlighting the mRNA cap-binding proteins and the regulation of GCN4 and CPA1 mRNAs.

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Section: Mrna Recruitment Of the 43s Picmentioning

confidence: 99%

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

2016

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“…It might be involved as translational control factor for other still unknown germ cell transcripts with extended and structural complex 5 ′ UTRs. This conclusion could be drawn because it was found for all other RNA helicases of the DDX3 protein subfamily conserved from yeast to men [60] .…”

Section: Azfa Locus and Gene Deletions And Male Infertilitymentioning

confidence: 99%

Human Y Chromosome and Male Infertility: Forward and Back from Azoospermia Factor Chromatin Structure to Azoospermia Factor Gene Function

Vogt¹,

Bender²,

Zimmer³

et al. 2017

Genetics of Human Infertility

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In the euchromatic part of the long arm of the human Y chromosome (Yq11) at least 13 Y genes encoding proteins and expressed in male germ cells were found in 3 distinct genomic Y regions frequently deleted in infertile men with idiopathic azoospermia, i.e., for unknown reasons no mature sperm were found in their semen fluid. Accordingly, they were designated as azoospermia factor (AZF) regions: AZFa, AZFb, and AZFc. Additionally, 10 Y genes called "testis-specific transcript Y" ( TTTY ) genes were mapped in the same AZF intervals. They belong to the long non-coding RNA gene pool in human germ cells because they seem to lack any protein-coding potential. Distinct chromatin regions in Yq11 overlapping with AZFb and AZFc are supposed to be involved in the premeiotic X and Y chromosome pairing and inactivation process controlling male germ cell meiosis. It can thus be assumed that the germ line function of the AZF loci in Yq11 may be not only based on the expression of some germ cell proteins, but also on the expression of some germ cell-specific TTTY transcripts and a locally dynamic and specific chromatin folding structure probably controlled by some germ cell-specific nuclear proteins.

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“…A high frequency of somatic DDX3 mutations has recently been identified in various cancers [1] . In Wnt-type medulloblastoma, DDX3 mutations often occur concurrently with a β-catenin mutation [18][19][20] .…”

Section: Research Highlightmentioning

confidence: 99%

“…DDX3 modulates several cellular processes, such as cell growth, apoptosis, innate immunity, and viral infection [1] and may function as an oncogene [1,2] . Examination of cancerous cells and clinical samples shows that DDX3 expression is positively correlated with malignancy and the stemness of different types of cancers [3][4][5][6] .…”

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confidence: 99%

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DDX3-mediated translational activation drives β-catenin signaling and cancer cell motility

Chen¹,

Tarn

2015

Can Cell Microenviron

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The DEAD box RNA helicase DDX3 regulates multiple steps in gene expression and also can mediate cell signaling. Dysregulation of DDX3 has been observed in various cancers, and, notably, its mutations are particularly associated with the wingless (Wnt) type of medulloblastoma. DDX3 can promote cell cycle progression, prevent apoptosis, and increase cell migration in some cancerous cells. Detailed mechanisms by which DDX3 modulates cell adhesion and migration and even the epithelial-mesenchymal transition have only just begun to emerge. We recently demonstrated that DDX3 generally modulates cell adhesion and migration properties in various cell lines, essentially via its activity in promoting the translation of Rac1 mRNA. Moreover, our results indicate that DDX3-activated Rac1 translation is required for Wnt-β-catenin signaling and supports the cell adhesion and migration activities of metastatic cancer cells. This DDX3-Rac1-β-catenin pathway suggests a new role for DDX3 in the Wnt type, and perhaps also other types, of medulloblastoma.To cite this article: Hung-Hsi Chen, et al. DDX3-mediated translational activation drives β-catenin signaling and cancer cell motility. Can Cell Microenviron 2014; 1: e392.

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The Ded1/DDX3 subfamily of DEAD-box RNA helicases

Cited by 158 publications

References 165 publications

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Mechanism and Regulation of Protein Synthesis in Saccharomyces cerevisiae

Human Y Chromosome and Male Infertility: Forward and Back from Azoospermia Factor Chromatin Structure to Azoospermia Factor Gene Function

DDX3-mediated translational activation drives β-catenin signaling and cancer cell motility

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