SUMMARYA new frequency-domain grouping robust fault diagnosis (GRFD) scheme, based on the design for both grouping-robust estimation=evaluation of component variation rate and Boolean-based decision process, is proposed for solving fault diagnosis of large-scale analog circuits with uncertainties, including both component tolerances and measurement errors. In this scheme, ÿrst, grouping-robust estimators for one partitioning of all component groups, designed by using grouping-full-column rank output measurement technique, are employed to estimate the component variation rate. Secondly, based on the faulty possibility judgment policy suggested in this research, grouping-robust evaluators are employed for the careful evaluation of component variation rate in order to reduce the e ect of both component tolerances and measurement errors on the diagnostic test result for one partitioning. Next, both repeating the same one-partitioning GRFD for a variety of partitionings and combining Boolean-based decision process, an overall GRFD scheme is proposed for achieving analog fault diagnosis. Finally, a fault diagnosis example of a large-scale analog circuit is illustrated. The results indicate that without any a priori information about the type of component failure, a precise t-diagnosable case for a large-scale circuit with component tolerances and measurement errors is accomplished at the lowest measurement cost.