The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

Yao, Hongyan; Xin, Danli; Li, Zijing

doi:10.1159/000523938

Cited by 2 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, DCP contributes part of the oxygen demand (10–15%) and nutrition necessary for the inner photoreceptor segments. Hypoperfusion of the DCP may lead to hypoxia and nutritional deficiency in these layers [ 45 , 46 ]. Studies have reported that decreased DCP density was related to the structural impairment in outer retina [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Wu,

Liu,

Liu

et al. 2024

Ophthalmol Ther

View full text Add to dashboard Cite

Introduction To evaluate the intraocular differences in optical coherence tomography (OCT)-based macular curvature index (MCI) among children with anisomyopia and to investigate the relationship between MCI and the macular microvasculature. Methods Fifty-two schoolchildren with anisometropia > 2.00 D were enrolled and underwent comprehensive examinations including cycloplegic refraction, axial length (AL), and swept source OCT/OCT angiography. OCT-based MCIs were determined from horizontal and vertical B-scans by a customized curve fitting model in MATLAB R2022 at 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea. Characteristics and topographic variation of MCI was analyzed, and the relationships with microvascularity and its associated factors were investigated. Results MCI achieved high reliability and repeatability. There were overall larger MCIs in the more myopic eyes than the less myopic eyes in 1-mm-, 3-mm-, and 6-mm-diameter circles at fovea (all p < 0.001). For the topographic variation, horizontal MCI was significantly greater than vertical MCI (all p < 0.001), and was the largest in 6-mm circle, followed by 3-mm and 1-mm circles. Stronger correlation of horizontal MCI with myopic severity than vertical MCI was found. Partial Pearson’s correlation found MCI was negatively associated with deep capillary plexus (DCP) vessel density ( p = 0.016). Eyes with a higher MCI in a 6-mm circle were more likely to have longer AL ( p < 0.001), lower DCP vessel density ( p = 0.037), and thinner choroidal thickness (ChT) ( p = 0.045). Conclusion Larger MCI was found in the more myopic eyes of children with anisomyopia and was significantly associated with smaller DCP density, suggesting that MCI was an important indicator of myopia-related retinal microvascularity change, and it could be a valuable metric for myopia assessment in children. Supplementary Information The online version contains supplementary material available at 10.1007/s40123-024-00956-5.

show abstract

Section: Discussionmentioning

confidence: 99%

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Wu,

Liu,

Liu

et al. 2024

Ophthalmol Ther

View full text Add to dashboard Cite

show abstract

Normative Perfusion Indices in the Emmetropic Nondiabetic and Healthy Highly Myopic Adult Population

MD,

2023

Optical Coherence Tomography Angiography for Choroidal and Vitreoretinal Disorders - Part 1

View full text Add to dashboard Cite

Reference values of optical coherence tomography angiography metrics vary according to the device used to measure them and even based on the software on the same device. There might exist measurement differences between different maps within the same device: Variables such as age, gender, and signal strength might induce changes in the measurement outputs. This chapter deals with the values of vessel length and vessel area densities, and foveal avascular zone values of healthy emmetropic people via the 3 × 3 mm map used in the most common equipment that are available commercially. The text includes metrics of the parafovea and fovea at the superficial, intermediate, and deep capillary plexuses. These measurements corresponded to the adult non-diabetic population and were distributed as center (foveal), inner (parafoveal) and full (whole map) densities, depending on the evaluated region, according to densities in the foveal, parafoveal, and whole map measurements. Metrics of the parafovea by subfield were also included. We also report current cut-off values that have been proposed as normality references in some variables. Values for the remaining metrics and devices can later be proposed. We dedicate a special section to non-diabetic patients with high myopia without pathology, which includes the same metrics as in emmetropic patients. The evaluation of perfusion indices benefits from the simultaneous measurement of metrics as well as regional evaluation. The signal strength is a key variable to consider.

show abstract

The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

Cited by 2 publications

References 37 publications

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia

Normative Perfusion Indices in the Emmetropic Nondiabetic and Healthy Highly Myopic Adult Population

Contact Info

Product

Resources

About