The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

Ruppert, Marina C.; Greuel, Andrea; Freigang, Julia; Tahmasian, Masoud; Maier, Franziska; Hammes, Jochen; Eimeren, Thilo van; Timmermann, Lars; Tittgemeyer, Marc; Drzezga, Alexander; Eggers, Carsten

doi:10.1002/hbm.25393

Cited by 60 publications

(40 citation statements)

References 74 publications

(86 reference statements)

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“…The PCC is a key region of the DMN with strong connectivity in primates with entorhinal cortex, parahippocampal gyrus, and, thus, hippocampal memory system, which is involved in autobiographical memory and imagining the future; and spatial navigation and scene processing (Leech and Sharp, 2014). Several prior studies have reported disrupted functional connectivity of the DMN in patients with PD by resting-state fMRI (Guo et al, 2021;Shang et al, 2021b;Wang et al, 2021) or fluorodeoxyglucose positron emission tomography (FDG-PET) (Ruppert et al, 2021;Schindlbeck et al, 2021;Shang et al, 2021a). However, how DMN dysfunction draws a relationship to cognitive symptoms in patients with PD still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Altered Default Mode Network Functional Connectivity in Parkinson’s Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Chen

Huang

et al. 2022

Front. Neurosci.

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PurposeWhether the intrinsic functional connectivity pattern of the default mode network (DMN) is involved in the progression of cognitive decline in Parkinson’s disease (PD) remains unclear. This study aimed to investigate the intrinsic functional connectivity (FC) pattern of the DMN anchored on the posterior cingulate cortex (PCC) in patients with PD by resting-state functional magnetic resonance imaging (fMRI).MethodsFifty patients with PD and 50 healthy controls (HCs) were included for resting-state fMRI scanning. A seed-based FC method was used to reveal FC patterns in the DMN with region of interest (ROI) in the PCC. Relationships between FC patterns and disease severity (UPDRS-III) were detected.ResultsCompared with the HCs, the patients with PD showed increased FC between the PCC and the right precuneus, left cuneus, and right angular gyrus. In the PD group, the increased FC values in the right precuneus were significantly and positively correlated with motor severity as assessed with UPDRS-III scores (rho = 0.337, p = 0.02).ConclusionOur result highlights that the patients with PD showed increased FC between the PCC and the right precuneus, left cuneus, and right angular gyrus in the DMN. The altered connectivity pattern in the DMN may play a crucial role in the neurophysiological mechanism of cognitive decline in patients with PD. These findings might provide new insights into neural mechanisms of cognitive decline in PD.

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Section: Introductionmentioning

confidence: 99%

Altered Default Mode Network Functional Connectivity in Parkinson’s Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Chen

Huang

et al. 2022

Front. Neurosci.

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“…It was reported that [C-11]-PE2I (N-(3-iodoprop-2E-enyl)-2b-carbomethoxy-3b-(4-methyl-phenyl)nortropane) (PE2I), a PET radiotracer targeting neuronal dopamine (DA) transporters with high specificity, avidity in the caudate, putamen, and pallidum was indicative of more severe cognitive function deficits ( Ivanidze et al, 2020 ). Moreover, PET imaging of glucose metabolism has shown lower levels of metabolic activity in the parietal, temporal, cingulate, and frontal cortices of patients with PD-MCI and PDD ( González-Redondo et al, 2014 ; Ruppert et al, 2021 ). The cholinergic system, which is responsible for cognitive processing and is associated with the clinical manifestations of PDD, plays an important role in the structural and functional remodeling of the cortical circuits ( Aarsland et al, 2017 ).…”

Section: Clinical Features Of Parkinson’s Disease Mild Cognitive Impairment and Parkinson’s Disease’s Disease Dementiamentioning

confidence: 99%

Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

Fan

Han

Zhao

et al. 2021

Front. Aging Neurosci.

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Parkinson’s disease (PD) is the second most common neurodegenerative disease. Cognitive impairment is one of the key non-motor symptoms of PD, affecting both mortality and quality of life. However, there are few experimental studies on the pathology and treatments of PD with mild cognitive impairment (PD-MCI) and PD dementia (PDD) due to the lack of representative models. To identify new strategies for developing representative models, we systematically summarized previous studies on PD-MCI and PDD and compared differences between existing models and diseases. Our initial search identified 5432 articles, of which 738 were duplicates. A total of 227 articles met our inclusion criteria and were included in the analysis. Models fell into three categories based on model design: neurotoxin-induced, transgenic, and combined. Although the neurotoxin-induced experimental model was the most common type that was used during every time period, transgenic and combined experimental models have gained significant recent attention. Unfortunately, there remains a big gap between ideal and actual experimental models. While each model has its own disadvantages, there have been tremendous advances in the development of PD models of cognitive impairment, and almost every model can verify a hypothesis about PD-MCI or PDD. Finally, our proposed strategies for developing novel models are as follows: a set of plans that integrate symptoms, biochemistry, neuroimaging, and other objective indicators to judge and identify that the novel model plays a key role in new strategies for developing representative models; novel models should simulate different clinical features of PD-MCI or PDD; inducible α-Syn overexpression and SH-SY5Y-A53T cellular models are good candidate models of PD-MCI or PDD.

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“…Therefore, these prominent findings are meaningful for the elucidation of pathophysiological course within motor loop in PD. Higher dReHo in precuneus and MTG, the major components of the DMN engaged in internally directed cognition, 52 were monitored along with the decreasing trend of CBF, resulting to the deviated CBF/ReHo ratio. This finding was supported by previous reports that revealed neuronal excitability 48 or hypoperfusion 53 in DMN.…”

Section: Discussionmentioning

confidence: 99%

Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease

Shang

et al. 2022

J Cereb Blood Flow Metab

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Pathological process in Parkinson’s disease (PD) is accompanied with functional and metabolic alterations. The time-varying properties of functional coherence and their coupling to regional perfusion are still rarely elucidated. To investigate early disruption of dynamic regional homogeneity (dReho) and neurovascular coupling in cognitively normal PD patients, dynamic neuronal synchronization and regional perfusion were measured using dReho and cerebral blood flow (CBF), respectively. Neurovascular coupling was assessed by CBF-ReHo correlation coefficient and CBF/ReHo ratio. Multivariate pattern analysis was conducted for the differentiating ability of each feature. Relative to healthy controls (HC) subjects, PD patients demonstrated increased dReho in middle temporal gyrus (MTG), rectus gyrus, middle occipital gyrus, and precuneus, whereas reduced dReho in putamen and supplementary motor area (SMA); while higher CBF/dReho ratio was located in putamen, SMA, paracentral lobule, and postcentral gyrus, whereas lower CBF/dReho ratio in superior temporal gyrus, MTG, precuneus, and angular gyrus (AG). Global and regional CBF-Reho decoupling were both observed in PD groups. The CBF/Reho ratio features achieved more powerful classification performance than other features. From the view of dynamic neural synchronization and neurovascular coupling, this study reinforced the insights into neural basis underlying PD and the potential role in the disease diagnosis and differentiation.

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The default mode network and cognition in Parkinson's disease: A multimodal resting‐state network approach

Cited by 60 publications

References 74 publications

Altered Default Mode Network Functional Connectivity in Parkinson’s Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Altered Default Mode Network Functional Connectivity in Parkinson’s Disease: A Resting-State Functional Magnetic Resonance Imaging Study

Experimental Models of Cognitive Impairment for Use in Parkinson’s Disease Research: The Distance Between Reality and Ideal

Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease

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