The defensive role of taurine against gonadotoxicity and testicular apoptosis effects induced by cisplatin in rats

Azab, Sherif; Kamel, I; Ismail, Nashaat Nabil; Hosni, Hossam El Din; Fatah, Mohamed Abd El

doi:10.1016/j.jiac.2019.07.004

Cited by 23 publications

(19 citation statements)

References 15 publications

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“…The resultant increase of mitochondrial membrane permeability enhances the leakage of cytochrome C from the mitochondria into the cytoplasm. Subsequently, caspase family of proteases is activated, and finally active caspase-3 executes apoptotic cell death [6,19]. Similarly, the present work showed that CSP administration caused significant increments of Bax and caspase-3 in rat stestes.…”

Section: Discussionsupporting

confidence: 67%

“…Moreover, phosphorylated JNK and p38 MAPKs induce the nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2) pathways resulting in increased production of pro-inflammatory mediators, as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and inflammatory prostaglandins, as prostaglandin E 2 (PGE 2 ) [4,5] . Eventually, activation of the apoptotic pathways ensues testicular cell death and male infertility [6].…”

Section: Introductionmentioning

confidence: 99%

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Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

Fouad

Khalaf

Akl

et al. 2020

JPRI

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The potential testicular protective effect of nimesulide (NSE) was studied in cisplatin (CSP)-challenged rats. NSE therapy (10 mg/kg/day, p.o.) was applied for 15 days, and a single dose of CSP (7 mg/kg, i.p.) was administered on the 10th day. CSP significantly decreased the levels of serum testosterone, testicular reduced glutathione, and superoxide dismutase. CSP also significantly increased testicular malondialdehyde, nitric oxide, tumor necrosis factor-α, interleukin-1β, cyclooxygenase-2 (COX-2), prostaglandin E2, nuclear factor-κB p65, Bax, and caspase-3. NSE significantly ameliorated all the biochemical changes observed in CSP-challenged rats. Moreover, NSE significantly reduced the histopathological injury, and the expressions of phosphorylated c-Jun N-terminal kinase (p-JNK) and p38 mitogen-activated protein kinases (MAPKs) in testes of rats received CSP. It was concluded that NSE significantly blocked the CSP-induced acute testicular injury in rats through inhibition of MAPK/COX-2 signaling pathway, and by combating oxidative stress, inflammation, and apoptosis.

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Section: Discussionsupporting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

Fouad

Khalaf

Akl

et al. 2020

JPRI

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“…Comparable protective anti-inflammatory results were also observed in traumatic brain injuries, as treatment with taurine was able to significantly reduce pro-inflammatory cytokines (including IL-1

, -1

, -4, -5, -6, -10, -12p70, -13, -17, TNF

, eotaxin, granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, interferon-γ, monocyte chemotactic protein-1, and vascular endothelial growth factor) and alleviate severity of the injury [ 137 , 138 ]. Finally, taurine supplementation has shown to protect cardiac [ 139 ], renal [ 140 , 141 , 142 ], and gonadal [ 143 ] tissue from cisplatin-induced toxicities, by reducing inflammation caused by oxidative and endoplasmic reticulum stress. Interestingly, while taurine supplementation shows anti-inflammatory effects, TauT deletion shows increased susceptibility [ 144 ] and loss of self-healing [ 145 ] to parasitic Malaria infection.…”

Section: Taurine the Innate Immune System And Potential Therapeumentioning

confidence: 99%

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

et al. 2020

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Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With its unique sulfonic acid makeup, taurine influences cellular functions, including osmoregulation, antioxidation, ion movement modulation, and conjugation of bile acids. Taurine exerts anti-inflammatory effects that improve diabetes and has shown benefits to the cardiovascular system, possibly by inhibition of the renin angiotensin system. The beneficial effects of taurine are reviewed.

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“…Similarly, CP reduced catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) expressions; however, it increased malondialdehyde (MDA) levels in the testicular tissues of mice (Zhang et al, 2020). On the other hand, CP caused lower testosterone levels and induced apoptosis via enhanced Bcl-2-associated X protein (Bax) and decreased B-cell lymphoma 2 (Bcl-2) levels in the testis of rats (Azab et al, 2020). Generally, CP-induced animals also exhibited lower sperm count and motility as well as higher abnormal sperm; however, testicular injury adversely affects spermatogenesis, sperm quality, and oxidative stress parameters in the related studies (Ceylan et al, 2020;Kohsaka et al, 2020;Saad et al, 2020;.…”

Section: Introductionmentioning

confidence: 99%

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

Aslan

Kumalar

Güzel

et al. 2021

Anatolian Journal of Botany

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Infertility has become an increasingly important health problem due to genetic, familial, hormonal, and congenital abnormalities, environmental and chemical reasons. This study aimed to investigate the effects of Panax ginseng (Pnx) root extract on cisplatin (CP) induced testicular damage of rats. Four animal groups were applied with different protocols as control, Pnx (200 mg / kg), CP (7 mg / kg), and CP + Pnx (200 mg / kg). At the end of the experiment, the body and testicular weights of the rats were measured. While free/total testosterone, total antioxidant capacity (TAC), and total oxidative species (TOS) levels were analyzed in blood samples, apoptotic cells were marked by TUNEL staining in testicular samples of rats. According to the results, free/total testosterone and TAC levels were decreased while TOS levels increased in injured rats' plasma. On the other hand, seminiferous tubule diameters widened, and the number of apoptotic cells increased in rats' testis. These variables were significantly improved with the consumption of Pnx. As a result, Pnx has a significant protective effect on testicular tissue; however, further studies are needed to elucidate its action mechanism.

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The defensive role of taurine against gonadotoxicity and testicular apoptosis effects induced by cisplatin in rats

Cited by 23 publications

References 15 publications

Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

Nimesulide Inhibits MAPK/COX-2 Pathway, and Prevents Oxidative Stress, Inflammation, and Apoptosis in Testes of Cisplatin-Challenged Rats

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Panax ginseng’in sıçanlarda sisplatin ile oluşturulan testis hasarı üzerine etkileri

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