The deficiency of FKBP-5 inhibited hepatocellular progression by increasing the infiltration of distinct immune cells and inhibiting obesity-associated gut microbial metabolite

Zhang, Chuantao; Cui, Xiang; Feng, Lian; Han, Zhiyi; Peng, Deti; Fu, Wenjun; Xing, Yufeng

doi:10.21037/jgo-21-71

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…On the other hand, FKBPs (mainly FKBP51 and FKBP52) and Cyp40 are overexpressed in steroid hormone-dependent cancers such as breast and prostate cancer [152][153][154]. Recently, a few groups have reported overexpression of FKBP10, FKBP11, FKBP5 in renal cancer and hepatocellular carcinoma [155][156][157].…”

Section: Cancermentioning

confidence: 99%

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Gurung,

Danielson,

Tasnim

et al. 2023

Biology

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Proline isomerization, the process of interconversion between the cis- and trans-forms of proline, is an important and unique post-translational modification that can affect protein folding and conformations, and ultimately regulate protein functions and biological pathways. Although impactful, the importance and prevalence of proline isomerization as a regulation mechanism in biological systems have not been fully understood or recognized. Aiming to fill gaps and bring new awareness, we attempt to provide a wholistic review on proline isomerization that firstly covers what proline isomerization is and the basic chemistry behind it. In this section, we vividly show that the cause of the unique ability of proline to adopt both cis- and trans-conformations in significant abundance is rooted from the steric hindrance of these two forms being similar, which is different from that in linear residues. We then discuss how proline isomerization was discovered historically followed by an introduction to all three types of proline isomerases and how proline isomerization plays a role in various cellular responses, such as cell cycle regulation, DNA damage repair, T-cell activation, and ion channel gating. We then explore various human diseases that have been linked to the dysregulation of proline isomerization. Finally, we wrap up with the current stage of various inhibitors developed to target proline isomerases as a strategy for therapeutic development.

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Section: Cancermentioning

confidence: 99%

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Gurung,

Danielson,

Tasnim

et al. 2023

Biology

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“…Adoptive transfer of ex vivo activated iNKT cells suppressed HCC development in mice (130). In Fkbp5 −/− mice treated with DEN, progression of HCC was inhibited and T cells, including iNKT cells, were significantly increased compared to WT (131). Hepatic iNKT, NK, and T cells express CXCR6 (83, 132).…”

Section: Inkt Cells In Hccmentioning

confidence: 99%

Innate-like T lymphocytes in chronic liver disease

Papanastasatou

Verykokakis²

2023

Front. Immunol.

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In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis. Foremost among these are innate-like T lymphocytes, including natural killer T (NKT) and mucosal-associated innate T (MAIT) cells, which are a population of specialized T cells with innate characteristics that express semi-invariant T cell receptors with non-peptide antigen specificity. As primary liver residents, innate-like T cells have been associated with immune tolerance in the liver, but also with a number of hepatic diseases. Here, we focus on the biology of NKT and MAIT cells and how they operate during the course of chronic inflammatory diseases that eventually lead to hepatocellular carcinoma.

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“…7 The FKBP5 deletion also affected the gut microbiota and prevented the development of obesity and metabolic phenotypes. 90…”

Section: Fkbp5 and Its Association With Several Metabolic Diseasesmentioning

confidence: 99%

FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease

Ma,

Yang,

Gao

et al. 2023

Journal of Investigative Medicine

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The FK506-binding protein (FKBP5) plays significant roles in mediating stress responses by interacting with glucocorticoids, participating in adipogenesis, and influencing various cellular pathways throughout the body. In this review, we described the potential role of FKBP5 in the pathogenesis of two common chronic liver diseases, metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease (ALD). We provided an overview of the FK-binding protein family, and elucidate their roles in cellular stress responses, metabolic diseases, and adipogenesis. We explored how FKBP5 may mechanistically influence the pathogenesis of MASLD and ALD and provided insights for further investigation into the role of FKBP5 in these two diseases.

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The deficiency of FKBP-5 inhibited hepatocellular progression by increasing the infiltration of distinct immune cells and inhibiting obesity-associated gut microbial metabolite

Cited by 6 publications

References 59 publications

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Proline Isomerization: From the Chemistry and Biology to Therapeutic Opportunities

Innate-like T lymphocytes in chronic liver disease

FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease

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