The Degree and Time‐Course Assessment of Radiation‐Induced Trismus Occurring After Radiotherapy for Nasopharyngeal Cancer

Wang, Chon-Jong; Huang, Eng‐Yen; Hsu, Hsuan-Chih; Chen, Hui‐Chun; Fang, Fu‐Min; Hsiung, Ching-Yeh

doi:10.1097/01.mlg.0000171019.80351.46

Cited by 148 publications

(122 citation statements)

References 15 publications

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“…Selection-induced problems were avoided by consecutive inclusion of patients. The 12-month follow-up inclusion criterion was established as it is unusual that patients develop trismus later than 12 months after RT completion [15]. Possible confounding factors, such as dose from brachytherapy, were accounted for in our analyses and predicted trismus rates by our models were in corresponded well with the observed rates.…”

Section: Discussionsupporting

confidence: 48%

Risk structures for radiation-induced trismus in head and neck cancer

et al. 2016

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Section: Discussionsupporting

confidence: 48%

Risk structures for radiation-induced trismus in head and neck cancer

et al. 2016

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“…This restriction in mouth opening may become severe and irreversible over time [5]. Recently, a multivariate prediction model for the course of mouth opening during and after radiotherapy was published [10].…”

mentioning

confidence: 99%

“…Fibrosis is considered one of the biological mechanisms leading to late radiation-induced side effects [3][4][5]. When the temporomandibular joint and masticatory muscles are irradiated, there is a risk of developing trismus [6,7].…”

mentioning

confidence: 99%

Predictors for trismus in patients receiving radiotherapy

et al. 2016

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Background: Trismus, a restricted mouth opening in head and neck cancer patients may be caused by tumor infiltration in masticatory muscles, radiation-induced fibrosis or scarring after surgery. It may impede oral functioning severely. The aims of our study were to determine: (1) the incidence of trismus at various time points; and (2) the patient, tumor, and treatment characteristics that predict the development of trismus after radiotherapy in head and neck cancer patients using a large database (n ¼ 641). Methods: Maximal mouth opening was measured prior to and 6, 12, 18, 24, 36, and 48 months after radiotherapy. Patient, tumor, and treatment characteristics were analyzed as potential predictors for trismus using a multivariable logistic regression analysis. Results: At six months after radiotherapy, 28.1% of the patients without trismus prior to radiotherapy developed trismus for the first time. At subsequent time points the incidence declined. Over a total period of 48 months after radiotherapy, the incidence of trismus was 3.6 per 10 person years at risk. Patients who had tumors located in the oral cavity, oropharynx or nasopharynx, and the salivary glands or ear, and who had a longer overall treatment time of radiotherapy, were more likely to develop trismus in the first six months after radiotherapy. Maximal mouth opening was a predictor for developing trismus at all time points. Conclusion: Incidence of trismus is 3.6 per 10 person years at risk. Tumor localization and overall treatment time of radiotherapy are predictors for developing trismus the first six months after radiotherapy. Maximal mouth opening is a significant predictor for developing trismus at all time points. Regular measurements of maximal mouth opening are needed to predict trismus.

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“…It arises from hypovascularization and fibrosis of the muscle tissue, manifesting from 3 to 6 months after radiation therapy 6,38 . According to Wang et al 38 , the muscles affected by trismus during cancer treatment are the masticatory or temporomandibular muscles. Tonic muscle spasms with or without fibrosis of the mastication muscles and TMJ (temporal-mandibular joint) can be minimized or prevented with jaw-opening exercises 3 .…”

Section: Trismusmentioning

confidence: 99%

Oral complications in patients receiving head and neck radiation therapy: a literature review

Sari¹,

Nasiloski

Gomes

2014

RGO, Rev. Gaúch. Odontol.

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Oral cancer is a relatively common disease worldwide and its incidence rate has increased over the years. In Brazil, thousands RESUMOO câncer bucal é uma doença relativamente comum a nível mundial e que vem aumentando a sua incidência ao longo dos anos. No Brasil, milhares de novos casos surgem e o cirurgião-dentista é o profissional que precisa estar preparado para diagnosticar, prevenir, intervir e orientar os pacientes quanto a doença, seu tratamento e as complicações inerentes ao mesmo. Não existe, atualmente, uma forma de tratamento sistêmico para o câncer que tenha a capacidade de destruir as células alteradas, sem causar dado ou a morte das células normais. A cirurgia combinada com a radioterapia é uma das formas mais comuns para tratamento dos tumores malignos de cabeça e pescoço. Essa modalidade de tratamento tem obtido altos índices de cura e sobrevida aos pacientes, porém, os efeitos colaterais existentes são graves e capazes de provocar morbidade aos pacientes, diminuindo a sua qualidade de vida. Desse modo, o objetivo do trabalho é realizar uma revisão de literatura sobre as principais complicações decorrentes do tratamento radioterápico, enfatizando a conduta do cirurgião-dentista frente a estas alterações.

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The Degree and Time‐Course Assessment of Radiation‐Induced Trismus Occurring After Radiotherapy for Nasopharyngeal Cancer

Cited by 148 publications

References 15 publications

Risk structures for radiation-induced trismus in head and neck cancer

Risk structures for radiation-induced trismus in head and neck cancer

Predictors for trismus in patients receiving radiotherapy

Oral complications in patients receiving head and neck radiation therapy: a literature review

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