The degree of cumulation of the “Bendamin” drug in the body of white rats

Varkholiak, I. S.; Gutyj, B. V.

doi:10.32718/nvlvet9415

Cited by 3 publications

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“…За впливу етилметилгідроксипіридину сукцинату встановлено зниження в кардіоміоцитах специфічного білка, що прискорює апоптоз. Також відбувається модулювання трансмембранних іонних струмів: сповільнюється повільний струм через кальцієві канали, відвертається блокада швидких натрієвих каналів та блокада швидко активованого компонента калієвого струму затриманого випрямлення (JKR) (Varkholiak & Gutyj, 2018;Varkholiak et al, 2019;.…”

Section: вступunclassified

“…Оскільки антиоксидантні сполуки можуть захищати здорові клітини та тканини організму собак від розвитку небажаних побічних ефектів, викликаних розвитком серцевої недостатності. Крім того, відомо, що у розвитку даної патології характерним є оксидативний стрес, який обумовлює особливу метаболічну активність антиоксидантів (Martyshuk, 2016;Varkholiak & Gutyj, 2019).…”

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The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure

Varkholiak

Gutyj

2021

SMLNUVMB

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Experimental studies obtained in recent years indicate the urgency of developing drugs of complex action to prevent the development of cardiovascular disease in dogs. This requires a much deeper study of the pathogenesis of heart failure, including cardiomyopathy. The aim of the study was to investigate the effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure. Two groups of dogs were formed for research: control (healthy) and experimental (sick). The 30-day experiment included 10 dogs of the control group and 10 dogs of the experimental (sick) breed of spaniel and dog 10–12 years of age. Treatment regimen for sick dogs: furosemide was administered orally on an empty stomach at 2 mg/kg every 12 hours; enalapril was administered orally at 0.5 mg/kg every 12 hours; bendamine was administered orally on an empty stomach at 20 mg/kg every 24 hours. It is recommended to divide the dose into two doses. An increase in the activity of aminotransferases (ALT by 59.2 %, AST – by 51.9 %) was found in the serum of dogs at heart failure. An increase in alkaline phosphatase activity was also found, which in the complex is an additional confirmation of changes in the heart muscle. Lactate dehydrogenase activity increased in the blood of sick dogs by 23.5 %. Minor changes in the content of total bilirubin and urea in the serum of sick dogs indicate the initial stage of liver pathology with impaired liver function due to congestion in the small circulation. This is also indicated by a decrease in the level of total protein in the blood of sick dogs, which was respectively 57.2 ± 3.57 g/l against the control group of 63.5 ± 4.15 g/l. On the basis of cardiac dysfunction and on the background of congestion, the function of not only the liver but also the kidneys is impaired (the so-called cardiorenal syndrome in heart failure). This is indicated by an increase in urea and creatinine by 38.5 and 36.9 %, respectively, compared with animals in the control group. The use of the drug “Bendamin” alleviated the manifestations of functional failure of the heart, liver and kidneys, as indicated by biochemical studies. Studies confirm the feasibility of using the drug “Bendamin” in dogs with the development of heart failure. The use of the drug “Bendamine” in patients with heart failure in dogs had a positive effect on the restoration of hematopoiesis and the normalization of biochemical parameters of the blood.

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Section: вступunclassified

The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure

Varkholiak

Gutyj

2021

SMLNUVMB

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“…Under the influence of ethylmethylhydroxypyridine succinate, a decrease in cardiomyocytes of a specific protein was found, which accelerates apoptosis. Transmembrane ionic currents are also modulated: slow current through calcium channels is slowed down, fast sodium channel blockade is averted, and the fast-activated potassium current component of delayed rectification (JKR) is blocked (Varkholiak & Gutyj, 2018;Varkholiak et al, 2019;.…”

Section: Introductionmentioning

confidence: 99%

“…Because antioxidant compounds can protect healthy cells and tissues of dogs from the development of unwanted side effects caused by the development of heart failure. In addition, it is known that the development of this pathology is characterized by oxidative stress, which causes a particular metabolic activity of antioxidants (Martyshuk, 2016;Varkholiak & Gutyj, 2019).…”

Section: Introductionmentioning

confidence: 99%

The effect of the drug “Bendamine” on the clinical and morphological parameters of dogs in heart failure

Varkholiak

Gutyj

Gufriy

et al. 2021

Ukr. Jour. of Vet. and Agr. Sci.

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The study aimed to investigate the effect of the drug “Bendamine” on dogs' clinical and morphological parameters in heart failure. Two groups of dogs were formed for research: control (healthy) and experimental (sick). The 30-day experiment included ten dogs from the control group, ten dogs of the observed (unhealthy) spaniel breed, and 10–12 years old dogs. The treatment regimen for sick dogs: furosemide was administered orally on an empty stomach at 2 mg/kg every 12 hours; enalapril was administered orally at 0.5 mg/kg every 12 hours; Bendamine was administered orally on an empty stomach at 20 mg/kg every 24 hours. It is recommended to divide the dose into two doses. In the study of hematopoiesis, we found that erythrocytes in dogs with heart failure increased by 18.2 %, while hemoglobin levels decreased by 1.8 %. Before treatment, red blood cell counts were found to reduce the mean hemoglobin in the erythrocyte and the mean erythrocyte volume. In the experimental group of dogs treated with the “Bendamine”, normalization of morphological blood parameters was found. The number of erythrocytes was 5.8 ± 0.06 T/L, and the hemoglobin level was 143.5 ± 4.7 g/L. The use of the drug “Bendamine” contributed to the gradual restoration of the functional state of the hematopoietic system in dogs with heart failure. This is also indicated by the red blood cell index of the dogs after the course of treatment. The therapy application in the experimental group significantly reduced the frequency and severity of shortness of breath and increased endurance during exercise. There was also a decrease in the frequency and duration of cough attacks. After treatment, signs, and intensity of ascites decreased in dogs of the experimental group. It has been suggested that this is due to an increase in myocardial contractile function due to the positive ionotropic action of Bendamine. The owners also recorded an improvement in appetite in animals after 30 days of therapy. Even in the dogs of the experimental group, after treatment, physical activity and emotional reactions improved. They were less depressed and more inclined to communicate with the owners. Thus, the use of the cardiac drug “Bendamine” in dogs with heart failure positively affected the restoration of hematopoiesis and the normalization of morphological parameters of the blood.

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“…The influence of the preparation "Bendamin" on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure. Ukrainian Journal of Veterinary and Agricultural Sciences, 3(1), 38-41. new therapeutic means in cardiovascular pathology is not enough (Trofimjak & Slivinska, 2016;Varkholiak & Gutyj, 2019;Varcholyak & Gutyi, 2019).…”

Section: Introductionmentioning

confidence: 99%

The influence of the preparation “Bendamin” on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure

Varkholiak¹,

Gutyj²

2020

Ukr. Jour. of Vet. and Agr. Sci.

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The purpose of this work was to study the influence of “Bendamin” on the morphological and biochemical indices of rat blood in experimental modeling of heart failure. The investigation were performed on white sexually mature young male-rats of Wistar line weighing 180–200 g, kept at the standard ration of the institute vivarium of the State Research Institute of Veterinary Preparations and Fodder Additives. To create a model of doxorubicin-induced cardiomyopathy, 24 male rats were selected. Animals were divided into 3 groups of 6 animals in each: control group – intact animals; experimental group E1, in which animals were modeled doxorubicin-induced cardiomyopathy by intraperitoneal injected of doxorubicin at a dose of 2.5 mg/kg 3 times a week for two weeks; experimental group E2, in which animals, after injection of doxorubicin, the preparation “Bendamin” was injected in the dose 20 mg/kg intragastrically. For experimental modeling of heart a decrease in the number of red blood cells was found in the blood of rats of the first experimental group by 34.7 % and hemoglobin level – by 24.2 %, with a simultaneous increase in the average hemoglobin content in one erythrocyte by 16.2 %. Doxorubicin-induced cardiomyopathy in rats of the first experimental group was accompanied by a decrease in leukocyte count by 22.2 %, an increase in uric acid level by almost in 2 times, creatinine by 11.4 %, cholesterol by 61.1 %. In the research of the protein synthesizing function of the liver of rats in experimental modeling of heart failure, a decrease in total protein by 9.6 % was found. These changes were accompanied by a slight decrease in albumin levels and a slight increase in globulin levels. By intoxication with doxorubicin, rats of the first experimental group showed a violation of the functional state of the liver, indicating an increase in the activity of aminotransferases in their blood, namely: AlAT by 34.2 %, AsAT – by 21.7 %, accordingly. Positive action of cardio preparation “Bendamin” on rats organism under conditions of creation of a model of doxorubicin-induced cardiomyopathy was installed, manifested by the normalization of hematological and biochemical parameters, functional status and protein synthesis of the liver.

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The degree of cumulation of the “Bendamin” drug in the body of white rats

Cited by 3 publications

References 3 publications

The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure

The effect of the drug “Bendamin” on the biochemical parameters of the blood of dogs in heart failure

The effect of the drug “Bendamine” on the clinical and morphological parameters of dogs in heart failure

The influence of the preparation “Bendamin” on the morphological and biochemical indices of blood of rats in experimental modeling of heart failure

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