The delaying effect of Qingxin Zishen decoction on ovarian aging: Examining regulation of ovarian mitochondria apoptosis in aged rats

Chen, Yun; Wu, Yinglan; Zhou, Yuxin; Teo, Yong Qing; Miao, Tingyu; Lei, Wen; Lu, Su

doi:10.1016/j.exger.2023.112298

Cited by 1 publication

(1 citation statement)

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“…Some of the key mechanisms through which TCM may contribute to the regulation of ovarian aging include enhancing mitochondrial biogenesis, improving mitochondrial function, modulating mitochondrial dynamics, and regulating mitochondrial quality control ( 120 ). For instance, the Qingxin Zishen decoction (QZD) has shown promise in delaying ovarian aging and mitigating age-related ovarian conditions by enhancing ovarian mitochondrial function and regulating ovarian mitochondrial apoptosis in older rats ( 83 ), providing potential treatment options for age-related ovarian changes.…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Targeting mitochondria for ovarian aging: new insights into mechanisms and therapeutic potential

Wang,

Liu

et al. 2024

Front. Endocrinol.

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Ovarian aging is a complex process characterized by a decline in oocyte quantity and quality, directly impacting fertility and overall well-being. Recent researches have identified mitochondria as pivotal players in the aging of ovaries, influencing various hallmarks and pathways governing this intricate process. In this review, we discuss the multifaceted role of mitochondria in determining ovarian fate, and outline the pivotal mechanisms through which mitochondria contribute to ovarian aging. Specifically, we emphasize the potential of targeting mitochondrial dysfunction through innovative therapeutic approaches, including antioxidants, metabolic improvement, biogenesis promotion, mitophagy enhancement, mitochondrial transfer, and traditional Chinese medicine. These strategies hold promise as effective means to mitigate age-related fertility decline and preserve ovarian health. Drawing insights from advanced researches in the field, this review provides a deeper understanding of the intricate interplay between mitochondrial function and ovarian aging, offering valuable perspectives for the development of novel therapeutic interventions aimed at preserving fertility and enhancing overall reproductive health.

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Section: Therapeutic Approachesmentioning

confidence: 99%