The deleterious effects of smoking in bone mineralization and fibrillar matrix composition

Barbosa, Alexandre Póvoa; Lourenço, Juliana Dias; Junqueira, Jader Joel Machado; França, Silva Larissa Emidio de; Martins, Janaina S.; Oliveira, Manoel Carneiro; Begalli, Isadora; Velosa, Ana Paula Pereira; Olivo, Clarice Rosa; Bastos, Thiago Bernardes; Jorgetti, Vanda; Paula, Vieira Rodolfo de; Teodoro, Walcy Rosolia; Lopes, Fernanda D.T.Q.S.

doi:10.1016/j.lfs.2019.117132

Cited by 22 publications

(27 citation statements)

References 30 publications

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“…The findings of this study showed that the reduction and delay of bone fracture healing in the smoke-exposed animals for 42 days was significantly associated with a decrease in serum IGF-1 levels. Consistent with the findings of the present study, a recent study by Barbosa et al indicated that the values of VEGF, IGF-1, and TGF-β decreased in mice exposed to cigarette smoking with tibial fractures ( 12 ). It has been reported that, after a fracture, the serum IGF-1 levels in smokers decreased, and this decrease in serum IGF-1 levels in patients was associated with the decreased bone union ( 41 ).…”

Section: Discussionsupporting

confidence: 93%

“…The study of Moghaddam et al showed that tibial fracture healing was 3–18 times longer in patients who had a history of smoking before and during the fracture than in patients who had no history of smoking ( 28 ). Furthermore, animal studies confirmed that exposure to cigarette smoke changes bone matrix composition and worsens bone mineralization ( 12 , 34 ). Consistent with most studies on cigarettes, our study showed that WTS, even for a short period of 4 weeks, has detrimental effects on bone repair.…”

Section: Discussionmentioning

confidence: 90%

“…Furthermore, TGF-β promotes the recruitment of osteoblasts and, eventually, the formation of new bone by stimulating the mobilization of bone marrow mesenchymal stem cells and osteoporotic cells. A decreased expression of TGF-β is seen in smokers ( 12 , 13 ). The reduction of TGF-β disrupts the migration, proliferation, and differentiation of mesenchymal cells (dependent on the TGF-β signaling pathway) and, in turn, delays ossification and bone repair in smokers ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

et al. 2021

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Background: Given the increasing use of waterpipe tobacco smoking in the world and its unknown effects on bone healing, this study investigated the repairing of femoral bone fractures in rats exposed to waterpipe tobacco smoking (WTS).Main Methods: This study involved 40 male Wistar rats that were divided into two groups, including the femoral fracture (Fx) and the Fx + WTS groups. Each group was divided into two subgroups that were evaluated for bone healing 28 and 42 days after femoral fracture. After fixing the fractured femur, the healing process was evaluated by radiography, pathological indicators, and a measurement of the blood levels of vascular endothelial growth factor (VEGF), parathyroid hormone (PTH), Ca ++, transforming growth factor-beta (TGF-β), and insulin-like growth factor 1 (IGF-1). Additionally, the density of VEGF and CD34 in fracture tissue was investigated by immunohistochemistry.Key Findings: Radiographic findings showed that factors related to the earlier stages of bone healing had higher scores in the Fx + WTS28 and 42 subgroups in comparison to the Fx groups. The density of VEGF and CD34 showed that the angiogenesis processes were different in the bone fracture area and callus tissue in the Fx +WTS subgroups. The serum levels of VEGF, TGF-β, and IGF-1 were significantly lower in the Fx +WTS42 group, and PTH in the Fx +WTS28 group was higher than that in the other groups.Significance: The findings showed the disturbance and delay in the femoral fracture union in rats exposed to hookah smoke. This is partly due to the reduction of molecular stimuli of bone synthesis and the attenuation of quantitative angiogenesis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

et al. 2021

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“…28 In a recent study, pernicious effects of smoking on bone mineralization and collagen synthesis were affected in a mouse model, demonstrating that mice exposed to cigarette smoke exhibited reduction of type I collagen deposition, which is critical for bone formation, which ultimately lead to slowed delayed bone formation rate. 29 Moreover, smoking was an independent predictor of worse trabecular strength in hip fracture patients. 30 As for the indirect effect of smoking on bone health, smoking was associated with decreased levels of parathyroid hormone 31 and vitamin D, 32 which could undermine bone integrity.…”

Section: Discussionmentioning

confidence: 96%

“…Calcium intake was reduced by smoking [ 27 ], and smoking detrimentally affected mRNA expression of bone-related markers [ 28 ]. In a recent study, pernicious effects of smoking on bone mineralization and collagen synthesis were affected in a mouse model, demonstrating that mice exposed to cigarette smoke exhibited reduction of type I collagen deposition, which is critical for bone formation, which ultimately lead to slowed delayed bone formation rate [ 29 ]. Moreover, smoking was an independent predictor of worse trabecular strength in hip fracture patients [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Impact of Cigarette Smoking on Fracture Risks in Subjective Cognitive Decline and Dementia: A Nationwide Longitudinal Study

Wang

Han

et al. 2020

Psychiatry Investig

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Objective We aimed to explore the differential impact of cigarette smoking on fracture risks in SCD and dementia.Methods A nationwide population-based cohort study design was used. Out of all the people aged 66 (n=1,555,103) who went through the National Screening Program from 2009–2014, 968,240 participants with eligible data were included in the study. Time-to-event was calculated as the duration between the NSPTA and fracture incidence. Cox proportional-hazard regression analyses were conducted to evaluate the risk of fractures.Results Increased risk of all [adjusted hazard ratio (aHR)=1.184; 95% confidence interval (CI)=1.184, 1.093–1.283], hip (aHR=1.518; 95% CI=1.168–4.972), vertebral (aHR=1.235; 95% CI=1.101–1.386) fractures were increased in current smokers with more than 20 or more pack years (≥20 py) of SCD group, after adjusting for all relevant confounding factors. In dementia group, however, current smokers ≥20 py were at reduced risk of hip fractures (aHR=0.249; 95% CI=0.089–0.97).Conclusion There was a disparate influence of cigarette smoking on the fracture risks in SCD and dementia group. Further studies are warranted to explicate this phenomenon, and personalized preventive measures according to one’s cognitive status are imperative, since risk factors of fractures can exert disparate influence on patients at different stage of cognitive trajectory.

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Leitfaden unikompartimenteller Gelenkknorpelschaden am Knie – Knorpelersatz, Osteotomie, Mini-Implantat oder Prothese?

Imhoff

2020

Orthopäde

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The deleterious effects of smoking in bone mineralization and fibrillar matrix composition

Cited by 22 publications

References 30 publications

The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

The Effect of Waterpipe Tobacco Smoking on Bone Healing Following Femoral Fractures in Male Rats

Differential Impact of Cigarette Smoking on Fracture Risks in Subjective Cognitive Decline and Dementia: A Nationwide Longitudinal Study

Leitfaden unikompartimenteller Gelenkknorpelschaden am Knie – Knorpelersatz, Osteotomie, Mini-Implantat oder Prothese?

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