The article focuses on the opening sequences in qualitative research interviews and in particular examines the interactive work of achieving ‘topic talk’. Using the concepts of activity types, activity frames and contextualization cues, a close-up analysis of eight focus-group interviews and 12 semi-structured interviews was conducted. The findings show that the interviewees display familiarity with the interview as an activity type and how it is to be socially organized. However, to create a joint focus of attention, thereby getting off to an adequate start, the participants also need to agree upon an activity frame and a distribution of positions to achieve a frame switch, which here emerges through the interactional work of announcing, customizing and approving. Accordingly, by highlighting the communicative and practical circumstances of qualitative research interviewing, the opening sequences are considered to be a delicate interactive affair, however, where the interviewer has to take the main responsibility.