The Delivery and Activation of Growth Factors Using Nanomaterials for Bone Repair

Li, Yiwei; Xu, Chun; Lei, Chang

doi:10.3390/pharmaceutics15031017

Cited by 8 publications

(1 citation statement)

References 164 publications

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“…T cells are also stimulated by biomaterials. For example, titanium dioxide nanorods with a high aspect ratio stimulate T cells, leading to a significant release of FGF-2 and promoting the proliferation of bone marrow-derived stem cells [131].…”

Section: Osteoimmunomodulatory (Oim) Effectsmentioning

confidence: 99%

Optimizing Delivery of Therapeutic Growth Factors for Bone and Cartilage Regeneration

Takematsu

Murphy

Hou

et al. 2023

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Bone- and cartilage-related diseases, such as osteoporosis and osteoarthritis, affect millions of people worldwide, impairing their quality of life and increasing mortality. Osteoporosis significantly increases the bone fracture risk of the spine, hip, and wrist. For successful fracture treatment and to facilitate proper healing in the most complicated cases, one of the most promising methods is to deliver a therapeutic protein to accelerate bone regeneration. Similarly, in the setting of osteoarthritis, where degraded cartilage does not regenerate, therapeutic proteins hold great promise to promote new cartilage formation. For both osteoporosis and osteoarthritis treatments, targeted delivery of therapeutic growth factors, with the aid of hydrogels, to bone and cartilage is a key to advance the field of regenerative medicine. In this review article, we propose five important aspects of therapeutic growth factor delivery for bone and cartilage regeneration: (1) protection of protein growth factors from physical and enzymatic degradation, (2) targeted growth factor delivery, (3) controlling GF release kinetics, (4) long-term stability of regenerated tissues, and (5) osteoimmunomodulatory effects of therapeutic growth factors and carriers/scaffolds.

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Section: Osteoimmunomodulatory (Oim) Effectsmentioning

confidence: 99%

Optimizing Delivery of Therapeutic Growth Factors for Bone and Cartilage Regeneration

Takematsu

Murphy

Hou

et al. 2023

Gels

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Nanoparticle‐Mediated Gene Delivery for Bone Tissue Engineering

Li,

Wu,

Cheng

et al. 2024

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Critical‐sized bone defects represent an urgent clinical problem, necessitating innovative treatment approaches. Gene‐activated grafts for bone tissue engineering have emerged as a promising solution. However, traditional gene delivery methods are constrained by limited osteogenic efficacy and safety concerns. Recently, organic and inorganic nanoparticle (NP) vectors have attracted significant attention in bone tissue engineering for their safe, stable, and controllable gene delivery. Targeted gene delivery guided by insights into bone healing mechanisms, coupled with the multifunctional design of NPs, is crucial for enhancing therapeutic outcomes. Here, the theoretical foundations underlying NP‐mediated gene therapy for enhancing bone healing across different histological stages are elucidated. Furthermore, the distinct attributes of functionalized NP vectors are discussed, and cutting‐edge strategies aimed at optimizing gene delivery efficiency throughout the therapeutic process are highlighted. Additionally, the review addresses the unresolved challenges and prospects of this technology. This review may contribute to the continued development and clinical application of NP‐mediated gene delivery for treating critical‐sized bone defects.

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