The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Bioprinting has gained immense attention and achieved the revolutionized progress for application in the multifunctional tissue regeneration. On account of the precise structural fabrication and mimicking complexity, hydrogel-based bio-inks are widely adopted for cartilage tissue engineering. Although more and more researchers have reported a number of literatures in this field, many challenges that should be addressed for the development of three-dimensional (3D) bioprinting constructs still exist. Herein, this review is mainly focused on the introduction of various natural polymers and synthetic polymers in hydrogel-based bioprinted scaffolds, which are systematically discussed via emphasizing on the fabrication condition, mechanical property, biocompatibility, biodegradability, and biological performance for cartilage tissue repair. Further, this review describes the opportunities and challenges of this 3D bioprinting technique to construct complex bio-inks with adjustable mechanical and biological integrity, and meanwhile, the current possible solutions are also conducted for providing some suggestive ideas on developing more advanced bioprinting products from the bench to the clinic.

Section: Polymer-based Bioprinting Hydrogels For Cartilage Tissue Engineeringmentioning

confidence: 99%

Advances of Hydrogel-Based Bioprinting for Cartilage Tissue Engineering

Han

Chang

Zhang

et al. 2021

“…Poly(ethylene glycol) (PEG) is hydrophilic and biocompatible polymer with a stealth-like behavior in vivo , and can be employed as another important class of tissue adhesives ( Knop et al, 2010 ; Wang et al, 2015 , 2018 ; Cao et al, 2018 ; Bian et al, 2020 ; Li et al, 2020 ; Tang et al, 2020 ; Yu et al, 2020 ). There are three main kinds of PEG-based tissue adhesives, including the photopolymerizable adhesives (FocalSeal ® , successor of AdvaSeal), PEG-trilysine adhesives (DuraSealTM) and functionalized PEG with two component adhesives (CoSeal ® , SprayGel).…”

Section: Synthetic Polymers-based Hemostatic Adhesivesmentioning

confidence: 99%

Recent Advances on Synthetic and Polysaccharide Adhesives for Biological Hemostatic Applications

Chen

Wang

et al. 2020

Self Cite

Rapid hemostasis and formation of stable blood clots are very important to prevent massive blood loss from the excessive bleeding for living body, but their own clotting process cannot be completed in time for effective hemostasis without the help of hemostatic materials. In general, traditionally suturing and stapling techniques for wound closure are prone to cause the additional damages to the tissues, activated inflammatory responses, short usage periods and inevitable second operations in clinical applications. Especially for the large wounds that require the urgent closure of fluids or gases, these conventional closure methods are far from enough. To address these problems, various tissue adhesives, sealants and hemostatic materials are placed great expectation. In this review, we focused on the development of two main categories of tissue adhesive materials: synthetic polymeric adhesives and naturally derived polysaccharide adhesives. Research of the high performance of hemostatic adhesives with strong adhesion, better biocompatibility, easy usability and cheap price is highly demanded for both scientists and clinicians, and this review is also intended to provide a comprehensive summarization and inspiration for pursuit of more advanced hemostatic adhesives for biological fields.

“…Bone, composed of collagen and calcium phosphate apatite crystals, is a well-known internal support system in higher vertebrates, which provides the rigidity, strength and a certain degree of elasticity to the living body. In recent years, on account of the increase of population aging, accidental injury, disease, trauma, obesity and weak physical activity in internal and external mediators, bone disorders and diseases are on the rise worldwide ( Amin et al, 2014 ; Saravanan et al, 2016 ; Baldwin et al, 2019 ; Wang et al, 2019 ; Yu et al, 2020 ). Although natural curing is a stable and reliable process, Patients with bone traumas always suffer from impaired healing and rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances of Chitosan-Based Injectable Hydrogels for Bone and Dental Tissue Regeneration

Tang

Tan

Zeng

et al. 2020

Self Cite

113

Traditional strategies of bone repair include autografts, allografts and surgical reconstructions, but they may bring about potential hazard of donor site morbidity, rejection, risk of disease transmission and repetitive surgery. Bone tissue engineering (BTE) is a multidisciplinary field that offers promising substitutes in biopharmaceutical applications, and chitosan (CS)-based bone reconstructions can be a potential candidate in regenerative tissue fields owing to its low immunogenicity, biodegradability, bioresorbable features, low-cost and economic nature. Formulations of CS-based injectable hydrogels with thermo/pH-response are advantageous in terms of their highwater imbibing capability, minimal invasiveness, porous networks, and ability to mold perfectly into an irregular defect. Additionally, CS combined with other naturally-derived or synthetic polymers and bioactive agents has proven to be an effective alternative to autologous bone and dental grafts. In this review, we will highlight the current progress in the development of preparation methods, physicochemical properties and applications of CS-based injectable hydrogels and their perspectives in bone and dental regeneration. We believe this review is intended as starting point and inspiration for future research effort to develop the next generation of tissue-engineering scaffold materials.