a b s t r a c t 8 A number of health problems are associated with significant stigma, a social phenomenon in which individuals 22 become the object of negative stereotypes. In addition to experiencing negative reactions from others, 23 stigmatised individuals and groups can experience harmful consequences when they internalise these negative 24 prevailing attitudes. The objective of this paper was to consider the potential to develop Internet-based health-25 related interventions explicitly targeting the effects of stigma on the individual. A review of the literature was 26 conducted to synthesise current conceptualisations of stigma and self-stigma across a number of groups, and 27 to identify current intervention developments. Self-stigma reduction strategies developed for in-person services 28 include cognitive reframing, myth busting, contact with other members of the stigmatised group, and disclosure 29 promotion. The development and provision of interventions targeting self-stigma within an online environment 30 is in its infancy. Our review considers there to be particular potential of online interventions for this target, 31 associated with the capacity of the Internet to promote having contact with peers within one's stigmatised 32 group, and for user interaction and empowerment. We conclude that self-stigma is a domain in which 33 there is significant potential for innovation with health-related interventions, and provide a number of 34 recommendations for online intervention development. 35