The dengue outbreak of 2014 transformed the epidemic characteristics of dengue in Guangdong Province, China

Wang, Ligui; Zhu, Bing; Zha, Lei; Jia, Leili; Qiu, Shaofu; Li, Peng; Du, Xinying; Sun, Yansong; Song, Hongbin

doi:10.1016/j.jinf.2019.03.001

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Dengue fever is the most important arboviral disease in tropical and subtropical areas and is especially prevalent in Southeast Asia , regions in the West Pacific Ocean, and Southern Africa (Radke et al, 2012; Schaffner and Mathis, 2014). This disease is caused by dengue virus transmitted by Aedes genus mosquitoes, mainly Aedes aegypti and Aedes albopictus (Asian tiger mosquito) (Knudsen, 1995), which are regarded as the primary dengue virus vector in mainland China and contribute to large dengue outbreaks with serious consequences, especially the 2014 outbreak in Guangzhou (Zhao et al, 2016; Luo et al, 2017), which was the worst in two decades (Wang et al, 2019). Furthermore, A. albopictus , which is one of world’s worst invasive alien species, exhibits great adaptability to diverse ecological conditions, and its geographic distribution is expanding through tropical and temperate regions (Mariangela et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

A Novel Densovirus Isolated From the Asian Tiger Mosquito Displays Varied Pathogenicity Depending on Its Host Species

Dong

Sun

et al. 2019

Front. Microbiol.

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Mosquito-borne viral diseases (MBVDs) continue to pose a significant global public health burden. Mosquito control remains a core intervention strategy in integrated mosquito management (IMM) programs to reduce the transmission of MBVDs. Mosquito densoviruses (MDVs) are mosquito-specific entomopathogenic viruses, and their attractive biological and pathogenic characteristics make MDVs potential biological control agents as alternatives to traditional chemical pesticides. However, different viral strains vary greatly in their pathogenicity against different mosquito species, which poses an obstacle for the wide application of MDVs in vector control. In this study, a novel MDV, Aedes albopictus densovirus-7 (AalDV-7), was isolated from field-collected Aedes albopictus in the dengue-endemic area of Guangzhou, China. The complete 4,048 nt genome of AalDV-7 was cloned and sequenced, and the transcription and translation of three open reading frames (ORFs) were characterized. Phylogenetic analysis indicated that AalDV-7 clustered with MDVs mostly isolated from indigenous mosquitoes. The pathogenicity of AalDV-7 to A. albopictus , Aedes aegypti , and Culex quinquefasciatus larvae was completely different, and the median lethal dose (LD 50 ) of AalDV-7 in A. albopictus which was 10 9.48 genome equivalents per ml (geq/ml) was 12 and 46 times lower than those in A. aegypti (10 10.56 geq/ml) and C. quinquefasciatus (10 11.15 geq/ml). Furthermore, the median lethal time (LT 50 ) value in A. albopictus (7.72 days) was 25% and 26% shorter than those in A. aegypti (10.24 days) and C. quinquefasciatus (10.42 days) at a titer of 10 11 geq/ml. Furthermore, the mortality of AalDV-7-infected mosquitoes increased in a dose-dependent manner, and the highest mortality was found in A. albopictus larvae exposed to 10 11 geq/ml AalDV-7 (82.00%). Sublethal effects analysis also showed that AalDV-7 infection significantly decreased pupation and emergence rates. The 1st–2nd instar larvae of all three mosquito species showed a near 100% infection rate, and the highest relative vial titer (305.97 ± 67.57 geq/ng) was observed in the 1st–2nd instar larvae of C. quinquefasciatus . These pathogenic characteristics make AalDV-7 a potential MBVDs control agent in China, whereas its negligible pathogenicity and high infection rate and viral dose in vivo make it a good candidate for gene delivery vectors in C. quinquefasciatus gene function analysis. In conclusion, the continuous discovery and isolation of new MDVs enrich the pool of mosquito entomopathogenic viruses and ...

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Section: Introductionmentioning

confidence: 99%

A Novel Densovirus Isolated From the Asian Tiger Mosquito Displays Varied Pathogenicity Depending on Its Host Species

Dong

Sun

et al. 2019

Front. Microbiol.

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Imported dengue fever and climatic variation are important determinants facilitating dengue epidemics in Southern Taiwan

Wang

Chen²,

Lin

et al. 2020

Journal of Infection

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Determination of Factors Affecting Dengue Occurrence in Representative Areas of China: A Principal Component Regression Analysis

Liu

Yue

et al. 2021

Front. Public Health

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Background: Determination of the key factors affecting dengue occurrence is of significant importance for the successful response to its outbreak. Yunnan and Guangdong Provinces in China are hotspots of dengue outbreak during recent years. However, few studies focused on the drive of multi-dimensional factors on dengue occurrence failing to consider the possible multicollinearity of the studied factors, which may bias the results.Methods: In this study, multiple linear regression analysis was utilized to explore the effect of multicollinearity among dengue occurrences and related natural and social factors. A principal component regression (PCR) analysis was utilized to determine the key dengue-driven factors in Guangzhou city of Guangdong Province and Xishuangbanna prefecture of Yunnan Province, respectively.Results: The effect of multicollinearity existed in both Guangzhou city and Xishuangbanna prefecture, respectively. PCR model revealed that the top three contributing factors to dengue occurrence in Guangzhou were Breteau Index (BI) (positive correlation), the number of imported dengue cases lagged by 1 month (positive correlation), and monthly average of maximum temperature lagged by 1 month (negative correlation). In contrast, the top three factors contributing to dengue occurrence in Xishuangbanna included monthly average of minimum temperature lagged by 1 month (positive correlation), monthly average of maximum temperature (positive correlation), monthly average of relative humidity (positive correlation), respectively.Conclusion: Meteorological factors presented stronger impacts on dengue occurrence in Xishuangbanna, Yunnan, while BI and the number of imported cases lagged by 1 month played important roles on dengue transmission in Guangzhou, Guangdong. Our findings could help to facilitate the formulation of tailored dengue response mechanism in representative areas of China in the future.

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The dengue outbreak of 2014 transformed the epidemic characteristics of dengue in Guangdong Province, China

Cited by 3 publications

References 5 publications

A Novel Densovirus Isolated From the Asian Tiger Mosquito Displays Varied Pathogenicity Depending on Its Host Species

A Novel Densovirus Isolated From the Asian Tiger Mosquito Displays Varied Pathogenicity Depending on Its Host Species

Imported dengue fever and climatic variation are important determinants facilitating dengue epidemics in Southern Taiwan

Determination of Factors Affecting Dengue Occurrence in Representative Areas of China: A Principal Component Regression Analysis

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