The Density Distribution in Ribbons from Roll Compaction

Abstract

The most important quality attribute in roll compaction/dry granulation is the ribbon porosity, as it predominantly determines the granule porosity and granule size distribution. The porosity, however, is not distributed homogeneously over the ribbon. In this study the porosity distribution was investigated using X-ray micro-computed tomography and demonstrated that characteristic distribution patterns exist over all three spatial directions, the ribbon length, width, and thickness. In detail the distribution patterns depend on the sealing system.

The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods

“…This is also the focus of different studies in the pharmaceutical area. Several studies like Sinka et al, Wray et al and Busignies et al investigated the density distribution inside pharmaceutical tablets ( Sinka et al, 2004 ; Wray et al, 2008 ; Busignies et al, 2006 ; Akseli et al, 2011 ), while other investigations consider the density distribution inside ribbons produced by roller compaction ( Akseli et al, 2011 ; Miguélez-Morán et al, 2009 ; Wiedey and Kleinebudde, 2017 ; Sun et al, 2018 ). Another focus of XMT measurements is the investigation of microcracks inside tablets and the correlation of the findings with the occurrence of tablet defects, (e.g.…”

Hyperspectral and Microtomographic Analyses to Evaluate the Stability of Quercetin and Calcium Effervescent Tablets Exposed to Heat and Ultraviolet Radiation

“…A single scan gives a series of data on dimensions, material characteristics, defects (e.g., pores or cracks), and internal structure in a non-destructive manner. Parameters such as density, pore structure, and porosity, obtained using this method, provide information on the microstructure of the tablet [41,42]. In addition, defects observed in the obtained image in the form of microcracks and delamination correlate with the mechanical properties of the tablets [3,37,43,44].…”