The dental structures in primary hyperparathyroidsm

Silverman, Sol; Gordan, Gilbert S.; Grant, Tianna; Steinbach, Howard L.; Eisenberg, Eugene; Manson, Richard

doi:10.1016/0030-4220(62)90375-4

Cited by 46 publications

(4 citation statements)

References 37 publications

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“…The occurrence of both PGCG and PHPT is more in females [12]. The ratio of female and male for PGCC is 2:1 and for PHPT is 3:1 [13,14]. Moreover, in this study female predilection is shown; posterior mandible is also the main occurring site accounting for 67% of the lesions.…”

Section: Discussionsupporting

confidence: 52%

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Limongelli

Tempesta

Lauritano

et al. 2020

JCM

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Peripheral giant cell granulomas (PGCG) associated with hyperparathyroidism (HPT) are rare clinical entities. The aim of this study is to report on 21 PGCGs of the oral cavity as the first clinical sign of unknown primary HPT (PHPT) referred to the Complex Operating Unit of Odontostomatology of Aldo Moro University of Bari from 2009 to 2019. Surgical treatment consisted in conservative enucleation of the lesion, if possible, with contextual bone rim osteoplasty with piezosurgical tools and following histological examination. After histological diagnosis of PGCG, PHPT screening was performed dosing parathyroid hormone and serum calcium. In all the patients haematological investigation demonstrated elevated values of parathyroid hormone and serum calcium ruling out an unknown PHPT. Specifically, after endocrinological evaluation, patients showed PHPT related to: parathyroid adenoma (13), parathyroid hyperplasia (two, one of which occurred in a intra-thyroidal parathyroid), and parathyroid carcinoma (1) and were scheduled for surgical treatment. Considering that PGCGs could represent the first clinical sign of an undiagnosed PHPT and the screening of PHPT is a non-invasive and cheap exam, in case of histological diagnosis of a giant cell lesion, both central and peripheral, especially in patients with synchronous or history of methacronous giant cell lesions, parathyroidal screening should be mandatory.

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Section: Discussionsupporting

confidence: 52%

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Limongelli

Tempesta

Lauritano

et al. 2020

JCM

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“…However, several authors have reported odontoclast peculiarities in vivo. No odontoclastic resorption can be found during hyperparathyroidism (Rosenberg and Gurainick, 1962;Silverman et al, 1962). Freilich (1971) demonstrated that parathyroid extract did not affect the morphology of odontoclasts.…”

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confidence: 95%

Cytodifferentiation of the odontoclast prior to the shedding of human deciduous teeth: An ultrastructural and cytochemical study

et al. 1996

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Background In human deciduous teeth, odontoclastic resorption takes place at the pulpal surface of the coronal dentine prior to shedding, and this resorption shows clear time‐related histological changes (Sahara et al., 1992). Methods Using this phenomenon as an observation system, we examined the cytodifferentiation of human odontoclasts by light and electron microscopy. For a histochemical marker of odontoclast differentiation and function, tartrate‐resistant acid phosphatase (TRAP) activity was determined by light and electron microscopic enzyme histochemistry. Results As root resorption neared completion, TRAP‐positive mononuclear cells were initially detected in the pulp chamber. They had abundant mitochondria, small lysosomes, and moderately developed rough endoplasmic reticulum throughout their cytoplasm. In these mononuclear cells, TRAP activity was localized in compartments of the biosynthetic pathway, i.e., in cisternae of the endoplasmic reticulum and Golgi lamellae, as well as small lysosomes. The TRAP‐positive mononuclear cells first made contact with the predentine surface by their elongated cellular processes. After attachment, they spread out along the predentine surface and developed specialized membrane structures, clear zones, and ruffled borders. Next, they fused with each other on the predentine surface and formed typical multinucleate odontoclasts. After termination of their resorption function, the odontoclasts lost their ruffled borders and became detached from the resorbed surface. Most of the detached odontoclasts had numerous large pale vacuoles and secondary lysosomes and appeared to be in the process of degeneration. Conclusions The present study demonstrates that: (1) odontoclasts differentiated from TRAP‐positive mononuclear cells, which presumably originate from circulating progenitor cells, (2) membrane specialization of odontoclasts, i.e., development of a clear zone and ruffled border, is induced following their contact with the resorption surface, (3) multinucleation of odontoclasts takes place only after their attachment to the resorption surface, (4) mature multinucleate odontoclasts can resorb predentine as well as dentine in the same way as osteoclasts resorb bone, and (5) at the end of the resorption, odontoclasts gradually lose their ruffled borders and become detached from the resorbed surface. © 1996 Wiley‐Liss, Inc.

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“…Both PGCG and PHPT have female predilection with female to male ratio; for PGCG, it is 2:1 and for PHPT, it is 3:1. [ 9 10 11 ] However, various cases had been reported affecting the male gender more. Chaparro-Avendano et al .…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] The ratio of female and male for PGCC is 2:1 and for PHPT is 3:1. [ 10 11 ] Hereby, we are presenting a rare case of PGCG with PHPT in a male patient.…”

Section: Introductionmentioning

confidence: 99%

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

Pattnaik

Rajguru

Pattanaik

et al. 2020

J Family Med Prim Care

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Peripheral giant cell granuloma (PGCG) known as “giant cell epulis” is a benign, reactive exophytic gingival lesion that accounts for less than 10% of all gingival lesions. PGCG affects females more than males with middle age predilection. Till now the etiology of PGCG remains unclear but various factors that can cause PGCG include poor oral hygiene, food impaction, following an extraction, dry mouth, hormonal disturbance, and hyperparathyroidism. The reported recurrence rate of the lesion is 5.0%–70.6%. The present case report describes the rare case of PGCG with primary hyperparathyroidism in a male patient with a history of swelling in the mandibular anterior region.

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The dental structures in primary hyperparathyroidsm

Cited by 46 publications

References 37 publications

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Peripheral Giant Cell Granuloma of the Jaws as First Sign of Primary Hyperparathyroidism: A Case Series

Cytodifferentiation of the odontoclast prior to the shedding of human deciduous teeth: An ultrastructural and cytochemical study

Coexistence of hyperparathyroidism and peripheral giant cell granuloma of the jaw: A rare case report

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