The dentine remineralization activity of a desensitizing bioactive glass‐containing toothpaste: an in vitro study

Abstract

Background: Dentine hypersensitivity occurs easily on exposed dentine. This study aimed to evaluate the effectiveness of a novel bioactive glass-containing toothpaste on dentine permeability and remineralization. Methods: Thirty dentine discs were divided into three groups of 10 specimens each. The groups corresponded to the following brushing treatments: no brush, distilled water, and bioactive glass-containing toothpaste (Novamin). The toothpaste was applied twice a day for 7 days. Dentine permeability was measured after ethylene-diamine-tetraacetic acid (EDTA) etching, initial application, 3-day application, 7-day application and citric acid challenge, respectively. The dentine morphology was investigated using scanning electron microscopy (SEM). Attenuated total reflection Fourier transform infrared (ATR ⁄ FTIR) spectroscopy was performed to monitor the mineral variation on demineralized dentine. Qualitative information of elemental variation before and after treatments on completely demineralized dentine was detected by energy dispersive X-ray (EDX) analysis. Results: The bioactive glass-containing toothpaste significantly reduced dentine permeability after the 7-day treatment and showed, under SEM, excellent resistance to acid challenge compared to the other groups. ATR ⁄ FTIR and EDX revealed increased mineral content after treatment with Novamin. Conclusions: As the innovative bioactive glass-containing toothpaste occlude dentinal tubules and resist acid challenge, it may be useful for the treatment of dentine hypersensitivity and dentine remineralization.

Effect of desensitizing toothpastes on dentin

“…There is no way to reproduce satisfactorily the pulpar pressure, although other studies have attempted to do so using hydraulic conductivity to analyze dentin permeability. 4,5,16 While this method does indeed apply constant pressure in an attempt to simulate normal pulpar conditions, it cannot reproduce other crucial factors, such as oral temperature, saliva flow, dental biofilm, and mastication.…”

<i>In vivo</i> analyses of the effects of polyamidoamine dendrimer on dentin biomineralization and dentinal tubules occlusion

“…Currently, many strategies have been developed to deal with DH. For example, calcium-phosphate 5) , potassium oxalate 6) , bioactive glasses 7) , fluoride 8) , and other materials have been used either in dentifrices or as single or multiple application agents to occlude dentinal tubules. However, there are no single desensitizing agent that can be considered ideal for this condition, since these materials have difficulties in replicating the hierarchical structure of mineral within the collagen matrix and do not fit well with natural dentin tissue.…”

Determination of chemical elements and cross-section hardness of sclerotic darkened human dentin

“…Despite the knowledge of the disease microbiology [11,17], dentin remineralizing potential, and properties of some restorative materials, the biological mechanisms of remineralization by the pulp-dentin complex are not fully understood.…”