The dependence of Raman signal intensity on particle size for crystal powders

Monitoring the recrystallisation of amorphous xylitol using Raman spectroscopy and wide-angle X-ray scattering

“…The models had three components and R 2 and Q 2 -values of 0.972 and 0.970 and 0.971 and 0.969 respectively. It is known that Raman-spectra are affected by variations in particle size, sample packing, fluorescence, instrument reproducibility and intra-and interday variatons in intensity (Heinz et al, 2007;Pellow-Jarman et al, 1996). The Raman-spectra in the present study had fluctuations in intensity and baseline variation, which explains the suitability of the commonly used MSC, SNV and 2nd derivatization as pretreatment methods (Johansson et al, 2005;Strachan et al, 2007;Rinnan et al, 2009).…”

Detection of Low Levels of Amorphous Lactose using H/D Exchange and FT-Raman Spectroscopy

“…First, Raman scattering intensities are known to be dependent upon particle size with a disparity of the order of 100 μm between two components having been reported as leading to observable differences (31). For this reason, a fine grade of crystalline lactose was used in order to minimize the discrepancy in particle size between the amorphous (<10 μm) and crystalline (approximately 40 μm) fractions.…”

The Effect of the Particle Size on the Fundamental Vibrations of the [CO32–] Anion in Calcite

“…121μm to 42μm particle size range, consistent with some previous findings on the relationship between constituent particle size in powders and Raman intensity. 20 A possible explanation for the phenomenon may reside in porosity reduction with progressive closer packing of finer grained particles, serving to enhance the intensity of the Raman signal. Table 2: Comparison of IR and Raman rates in intervals A, B and C (see Figure 6).…”

“…Specifically how the type-behaviors of [CO3 2-] internal modes in calcite as described by infrared spectroscopy find expression in relation to particle size effects detectable in Raman spectroscopy, although available evidence suggests that the absolute intensity of the [CO3 2-] internal modes of carbonate minerals do vary as a function of powder particle size ranges. 6,20 To this end this study examines the effects of powder particle size ranges and the optically thick to thin transition on the fundamental 6 vibrations of the [CO]3 2-anion in calcite by attenuated total reflectance mid-infrared (ATR-IR) and Raman spectroscopy (RS).…”