The Dependence of RBE on the Energy of Fast Neutrons: 1. Physical Design and Measurement of Absorbed Dose

Rossi, Harald H.; Bateman, J. L.; Bond, V.P.; Goodman, L.J.; Stickley, E. E.

doi:10.2307/3570941

Cited by 44 publications

(8 citation statements)

References 7 publications

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“…3), as described by Rossi et al . ( 14 ). This chamber is intended for use in a mixed neutron- and gamma-field measurement and features an interchangeable internal TE plastic sleeve.…”

Section: Neutron Dosimetrymentioning

confidence: 99%

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Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device

Randers-Pehrson

Turner

et al. 2015

Radiation Research

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We describe here an accelerator-based neutron irradiation facility, intended to expose blood or small animals to neutron fields mimicking those from an improvised nuclear device at relevant distances from the epicenter. Neutrons are generated by a mixed proton/deuteron beam on a thick beryllium target, generating a broad spectrum of neutron energies that match those estimated for the Hiroshima bomb at 1.5 km from ground zero. This spectrum, dominated by neutron energies between 0.2 and 9 MeV, is significantly different from the standard reactor fission spectrum, as the initial bomb spectrum changes when the neutrons are transported through air. The neutron and gamma dose rates were measured using a custom tissue-equivalent gas ionization chamber and a compensated Geiger-Mueller dosimeter, respectively. Neutron spectra were evaluated by unfolding measurements using a proton-recoil proportional counter and a liquid scintillator detector. As an illustration of the potential use of this facility we present micronucleus yields in single divided, cytokinesis-blocked human peripheral lymphocytes up to 1.5 Gy demonstrating 3- to 5-fold enhancement over equivalent X-ray doses. This facility is currently in routine use, irradiating both mice and human blood samples for evaluation of neutron-specific biodosimetry assays. Future studies will focus on dose reconstruction in realistic mixed neutron/photon fields.

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“…3), as described by Rossi et al . ( 14 ). This chamber is intended for use in a mixed neutron- and gamma-field measurement and features an interchangeable internal TE plastic sleeve.…”

Section: Neutron Dosimetrymentioning

confidence: 99%

“…“The dependence of RBE on the energy of fast neutrons: 1. Physical design and measurement of absorbed dose.” Radiat Res 1960; 13:503–20 ( 14 ), modified and republished with the permission of Radiation Research .…”

Section: Figmentioning

confidence: 99%

Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device

Randers-Pehrson

Turner

et al. 2015

Radiation Research

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“…The physical phantoms for other animals that are available do not offer nearly the level of detail and usefulness as their anthropomorphic counterparts. Physical mouse phantoms, for example, have had minimal development in the 50 years since Rossi et al filled a Lucite cylinder with tissue equivalent liquid to act as a mouse phantom (Rossi et al , 1960). Broerse et al used a phantom with embedded thermoluminescent detectors, but the mouse phantoms were simply rectangular prisms (Broerse et al , 1978).…”

Section: Introductionmentioning

confidence: 99%

Construction of mouse phantoms from segmented CT scan data for radiation dosimetry studies

et al. 2015

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We present the complete construction methodology for an anatomically accurate mouse phantom made using materials which mimic the characteristics of tissue, lung, and bone for radiation dosimetry studies. Phantoms were constructed using 2 mm thick slices of tissue equivalent material which was precision machined to clear regions for insertion of lung and bone equivalent material where appropriate. Images obtained using a 3D computed tomography (CT) scan clearly indicate regions of tissue, lung, and bone that match their position within the original mouse CT scan. Additionally, radiographic films are used with the phantom to demonstrate dose mapping capabilities. The construction methodology presented here can be quickly and easily adapted to create a phantom of any specific small animal given a segmented CT scan of the animal. These physical phantoms are a useful tool to examine individual organ dose and dosimetry within mouse systems that are complicated by density inhomogeneity due to bone and lung regions.

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“…This procedure was repeated three times, then compressed air was allowed to flow through the fixture at a slight positive pressure (about 102 mm of water) for about 1 hour before irradiation . Neutron dosimetry using both exposure fixtures was consistent with established techniques for monenergetic neutron studies and microdosimetry (Goodman and Koch 1969, Rossi 1967, Rossi, Bateman, Bond, Goodman and Stickley 1960 . Additional experimental conditions are given in tables 1-3 .…”

Section: Methodsmentioning

confidence: 67%

An Elusive Factor Affecting Mutation Frequency inTradescantiaStamen Hairs: Its Influence on R.B.E.

Underbrink

Sparrow

Sautkulis

et al. 1975

International Journal of Radiation Biology and Related Studies

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A comparison of data from several experiments designed to determine either relative biological effectiveness (r.b.e.) or oxygen-enhancement ratios (o.e.r.) as a function of neutron energy revealed a puzzling variability in mutational response for pink mutations in Tradescantia stamen hairs. For some reason that we cannot determine, when the exposure fixtures and accompanying experimental procedures were changed as necessitated by the two studies, the expected mutation frequencies changed for X-rays and for four neutron energies. The other four neutron energies gave the expected results. As a consequence of these changes in mutation frequencies, the magnitude of r.b.e. values changed as well as the relationship of r.b.e. to neutron energy. Consequently, when r.b.e. values were determined using a closed but aerated exposure fixture instead of exposures made in free air, the resulting r.b.e. versus neutron-energy curve more closely paralleled that found by others for the inhibiton of root growth in Vicia faba.

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The Dependence of RBE on the Energy of Fast Neutrons: 1. Physical Design and Measurement of Absorbed Dose

Cited by 44 publications

References 7 publications

Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device

Accelerator-Based Biological Irradiation Facility Simulating Neutron Exposure from an Improvised Nuclear Device

Construction of mouse phantoms from segmented CT scan data for radiation dosimetry studies

An Elusive Factor Affecting Mutation Frequency inTradescantiaStamen Hairs: Its Influence on R.B.E.

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