The deposition of ingested silver in the rat kidney at different ages

Creasey, Margaret; Moffat, D. B.

doi:10.1007/bf01926506

Cited by 20 publications

(16 citation statements)

References 16 publications

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“…32 The deposition of ingested Ag in rat kidney also exhibited a varied Ag density and Ag granule distribution between young and adult animals. 33 Abundant Ag-binding substances in the liver and kidney or slow excretion of Ag through the bile duct or urine in chicks may also contribute to the high Ag deposition observed in both organs. Explaining this discrepancy requires a longterm toxicity evaluation of AgNP/NSP in rats and comparing the safety and organ distribution of the nanohybrid with that of pure AgNPs.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

Chiao¹,

Lin²,

Shen³

et al. 2012

IJN

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Developing effective and safe drugs is imperative for replacing antibiotics and controlling multidrug-resistant microbes. Nanoscale silicate platelet (NSP) and its nanohybrid, silver nanoparticle/NSP (AgNP/NSP), have been developed, and the nanohybrids show a strong and general antibacterial activity in vitro. Here, their efficacy for protecting Salmonella-infected chicks from fatality and septicemia was evaluated. Both orally administrated NSP and AgNP/ NSP, but not AgNPs alone, effectively reduced the systemic Salmonella infection and mortality. In addition, quantitative Ag analyses demonstrated that Ag deposition from AgNP/NSP in the intestines was less than that from conventional AgNPs, indicating that the presence of NSP for immobilizing AgNPs reduced Ag accumulation in tissue and improved the safety of AgNPs. These in vivo results illustrated that both NSP and AgNP/NSP nanohybrid represent potential agents for controlling enteric bacterial infections.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

Chiao¹,

Lin²,

Shen³

et al. 2012

IJN

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“…The kidneys suffer from an accumulation of AgNPs when the particles circulate in the vascular system [7], and most of the particles in the renal tissue are not eliminated or excreted, but precipitate [8,9]. Previous studies showed uncleared silver deposited in the renal glomerular basement membrane [10][11][12] and mesangium [13]. Therefore, it is of enormous interest to investigate the potential involvement of basement membrane pathology in renal disorder caused by AgNPs and the correlated molecular mechanism.…”

Section: Introductionmentioning

confidence: 98%

Hyaluronan up-regulation is linked to renal dysfunction and hearing loss induced by silver nanoparticles

Feng

Pyykkö

Zou

2014

Eur Arch Otorhinolaryngol

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Increased application of silver nanoparticles (AgNPs) has raised concerns on their potential adverse effects on human health. However, the precise toxicological mechanisms are not known in detail. The current study hypothesized that AgNPs induced glycosaminoglycan accumulation in the basement membrane that associated with the up-regulation of its component hyaluronic acid, known as a hydrophilic molecule of binding and retaining water, and caused toxicities in the kidney and cochlea. Rats administered AgNPs through either intravenous or intratympanic injection were observed at different time points after exposure. The concentrations of creatinine and urea in the serum were elevated remarkably, and proteins leaked into the urine were increased. A significant hearing loss over a broad range of frequencies was indicated. AgNP exposure induced glycosaminoglycan accumulation and hyaluronic acid up-regulation in the basement membrane. Abundant apoptotic cell death was demonstrated in the AgNP-exposed organs. Our results suggested that glycosaminoglycan accumulation associated with the up-regulation of hyaluronic acid was involved in the toxicities of kidney and cochlea caused by AgNPs.

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“…In kidneys, it was shown that the unfiltered silver was deposited in the renal glomerular basement membrane (Ham and Tange 1972;Moffat and Creasey 1972;Creasey and Moffat 1973;Danscher 1981), mesangium (Day et al 1976), Kupffer cells, and sinusoid endothelium cells in the liver (Danscher 1981). A major silver deposit was found in the digestive tract during oral toxicity experiments (Loeschner et al 2011;Van der Zande et al 2012).…”

Section: Toxicity and Toxicocinetics Of Agnps After Oral Intakementioning

confidence: 93%

Silver nanoparticles: Their potential toxic effects after oral exposure and underlying mechanisms – A review

Gaillet

Rouanet

2015

Food and Chemical Toxicology

256

138

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The deposition of ingested silver in the rat kidney at different ages

Cited by 20 publications

References 16 publications

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection

Hyaluronan up-regulation is linked to renal dysfunction and hearing loss induced by silver nanoparticles

Silver nanoparticles: Their potential toxic effects after oral exposure and underlying mechanisms – A review

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