The derived neutrophil/lymphocyte ratio predicts poor clinical outcome in soft tissue sarcoma patients

Evaluation of leukocyte counts and neutrophil‐to‐lymphocyte ratio as predictors of local recurrence of feline injection site sarcoma after curative intent surgery

“…Moreover, granulocytes and granulocyte‐macrophage colony‐stimulating factors are produced by some solid tumours and are known to modulate their progression in people . On the other hand, T‐lymphocyte subsets are crucial in specific antitumor immunity, and lymphopenia has been correlated with a worse prognosis in human patients with solid tumours . As a consequence, a high NLR may reflect a less effective immune response against cancer, with a predominant neutrophilic response and relative lymphopenia, which promotes tumour growth and dissemination …”

“…44,45 On the other hand, T-lymphocyte subsets are crucial in specific antitumor immunity, and lymphopenia has been correlated with a worse prognosis in human patients with solid tumours. 46 As a consequence, a high NLR may reflect a less effective immune response against cancer, with a predominant neutrophilic response and relative lymphopenia, which promotes tumour growth and dissemination. 23,43,47 In the light of such considerations, the absence of a correlation between LC and both LR and OST in the sampled population is surprising; however, it may be hypothesized that the efficacy of the host immune response against cancer is more influenced by the subpopulations of lymphocytes than by the absolute lymphocyte count, as suggested by results of previous studies on dogs.…”

Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer

“…NLR is an independent prognostic factor of survival in patients with upper gastrointestinal cancers and several types of solid organ malignancies (Walsh et al 2005;Jung et al 2011;Chen et al 2015;Duzlu et al 2015;Langsenlehner et al 2015;Okamura et al 2015;Song et al 2015;Szkandera et al 2015;Ji et al 2016). However, there are a few studies regarding the thyroid cancers.…”

Can Multistate Modeling of Local Recurrence, Distant Metastasis, and Death Improve the Prediction of Outcome in Patients With Soft Tissue Sarcomas?

“…Five hundred thirty-nine patients with histologically verified localized soft tissue sarcoma undergoing surgery with curative intent between June 1995 and May 2015 at the Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria, represented the population of this single-center, historical cohort study. Detailed inclusion and exclusion criteria were reported previously [14]. Baseline and outcome data were retrieved retrospectively from our prospectively maintained in-house electronic healthcare database as previously described [6].…”