This study investigates the effectiveness of a 10-week multicomponent PPI, the Inspired Life Program (ILP), in promoting the mental health and reducing self-reported symptoms of depression and negative affect in a non-clinical, rural Ghanaian adult sample. Although previous research has examined group-based well-being interventions in developing countries (e.g. Bonthuys, Botha, Nienaber, Freeka, & Kruger, 2011; Rugira et al., 2015; Teodorczuk et al., 2019; Van Zyl & Rothmann, 2012), as far as can be established, there is a lack of research examining the effectiveness of a PPI group-based intervention model in Ghana. The ILP differs from the existing PPI programs in that it offers a multicomponent PPI (mPPI) at a group level for a rural poor, non-English speaking sample. Given that a group-based model is more cost-effective (since the costs of mental health professionals are distributed across several people, rather than a single individual), a successful intervention could have important policy implications, in that it would offer a cheaper alternative to delivering mental health improvements. Nonetheless, there is ample evidence to support both individualized (e.g.