The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

Akhgari, Abbas; Dezfuli, Abdolmaohammad Ghalambor; Rezaei, Mohammadebrahim; Kiarsi, Mohammad; Abbaspour, Mohammadreza

doi:10.17795/jjnpp-33613

Cited by 34 publications

(25 citation statements)

References 32 publications

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“…Erosion studies are important because, based on the desired application, films absorbing and maintaining their physical integrity are as useful as those that absorb solvents and then erode over time. The former properties are more suitable for filtration applications while the latter could have important pharmaceutical applications where they can be used for controlled release formulation of some highly soluble drugs …”

Section: Resultssupporting

confidence: 67%

Modification of absorbent poly(glycerol‐glutaric acid) films by the addition of monoglycerides

Boakye

Jones

Latona

et al. 2017

J of Applied Polymer Sci

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Monoglycerides (MGs) have been incorporated into the matrix of poly(glycerol-co-glutaric acid) films to investigate their effect on the thermal, mechanical, and solvent absorption properties of the resultant films. Solvent absorption studies revealed that poly(glycerol-co-glutaric acid-co-MG) films were able to absorb and resorb solvents better than poly(glycerol-co-glutaric acid) films, albeit they had higher erosion levels. Thermogravimetric analysis showed that the incorporated MGs did not affect the thermal stability of the glycerol-based films. The MG-incorporated films were observed to be much softer than the poly(glycerol-co-glycerol) films which was further proven by a 39-fold reduction in Young's Modulus and 17-fold reduction in fracture energy when compared to the poly(glycerol-co-glycerol). Mechanical property studies also revealed that the incorporation of MGs increased the elongation % and reduced the tensile strength of poly(glycerol-co-glutaric acid) films. Correlation analysis revealed a strong linear relationship between Young's Modulus and fracture energy (R 2 5 0.9962), and between Young's Modulus and tensile strength (R 2 5 0.9972). Our study proved that MGs can be successfully incorporated in the polymer matrix of poly(glycerol-co-glutaric acid) films to produce softer films with increased elongation and increased solvent absorption capacity.

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Section: Resultssupporting

confidence: 67%

Modification of absorbent poly(glycerol‐glutaric acid) films by the addition of monoglycerides

Boakye

Jones

Latona

et al. 2017

J of Applied Polymer Sci

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“…The formation of the gel layer not only hinders the release of the drug but also decreases the rate of erosion of the tablets. 30,31 When different statistical models were applied to the evaluation of the release pattern of the drug, it was found that formulations F1, F2, F3, F5, F6s and F8 followed the Higuchi model whereas F4 and F7 followed the Korsmeyer-Peppas model and F9 followed the zero-order kinetics model. The value of n showed that the release of the drug from formulations F1 to F8 followed Fick's diffusion (case 1 transport/ anomalous transport) as the value of n < 0.49 and F9 followed non-Fickian.…”

Section: Discussionmentioning

confidence: 99%

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Zaman¹,

Rasool²,

Ali³

et al. 2014

Adv Polym Technol

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ABSTRACT:The basic purpose of the current study was to formulate controlled release matrix tablets loaded with loxoprofen sodium using pectin and hydroxypropylmethyl cellulose (HPMC). The effect of these polymers on the release pattern of drug from the formulated matrix system was evaluated. Different concentrations of these polymers alone as well as polymeric blends were used in tablets formulation using wet granulation technique. The differential scanning calorimetric technique was used to detect the chemical interactions between ingredients. Precompression studies were done to assess fineness and flow properties of the granules. Hardness, friability, weight variations, and percentage drug contents were calculated for the evaluation of compressed tablets. F9 formulated in the combination of HPMC and pectin in the ratio of 30:10 showed better retardation during dissolution studies. Upon application of statistical models, the diffusion process was found to be dominant for drug release following the Higuchi model. HPMC and pectin were found suitable for the formulation of controlled release matrix tablets. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21493; View this article online at wileyonlinelibrary.com.

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Section: Resultsmentioning

confidence: 99%

Synthesis of absorbent polymer films made from fatty acid methyl esters, glycerol, and glutaric acid: Thermal, mechanical, and porosity analyses

Boakye

Jones

Latona

et al. 2019

J of Applied Polymer Sci

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In previous studies, monoglycerides (MGs) were incorporated into the matrix of poly(glutaric acid–glycerol) films to investigate their effect on the thermal, mechanical, and solvent absorption properties of the resultant films. In this study, the same properties were monitored when fatty acid methyl esters (FAME) were added to the polymer film formulation. Thermogravimetric analysis showed that, while the decomposition profile of the FAME and MG‐infused films were different, the final decomposition temperatures were similar for both film types at approximately 400 °C. Degree of branching (DB%) was calculated from nuclear magnetic resonance data and was used to examine the effect of DB% on the mechanical and absorption properties of the films. Experimental results did not show any correlation with DB% and any of the physical, chemical, mechanical, or thermal properties studied. Relative to the poly(glycerol–glutaric acid) control, the incorporation of MG into the polymer matrix resulted in improved % absorption but decreased the mechanical property values. Conversely, adding FAME into the matrix improved the mechanical property values; however, there was no significant change in the % absorption values relative to the control. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47822.

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The Design and Evaluation of a Fast-Dissolving Drug Delivery System for Loratadine Using the Electrospinning Method

Cited by 34 publications

References 32 publications

Modification of absorbent poly(glycerol‐glutaric acid) films by the addition of monoglycerides

Modification of absorbent poly(glycerol‐glutaric acid) films by the addition of monoglycerides

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Synthesis of absorbent polymer films made from fatty acid methyl esters, glycerol, and glutaric acid: Thermal, mechanical, and porosity analyses

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