The design and fabrication of nanoengineered platinum needles with laser welded carbon nanotubes (CNTs) for the electrochemical biosensing of cancer lymph nodes

Zandi, Ashkan; Sh, Zahra Davari; Shojaeian, Fatemeh; Mousavi-Kiasary, S M Sadegh; Abbasvandi, Fereshteh; Zandi, Afsoon; Gilani, A. Ghanadzadeh; Saghafi, Zohre; Kordehlachin, Yasin; Mamdouh, Amir; Miraghaie, Seyyed Hossein; Hoseinyazdi, Meisam; Khayamian, Mohammad Ali; Anbiaee, Robab; Faranoush, Mohammad; Abdolahad, Mohammad

doi:10.1039/d1bm00875g

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…The histological hematoxylin and eosin staining (H&E) method was used for morphological and pathological evaluation of the tumor samples. Each slide was photographed using a camera coupled to the microscope (Olympus-BX51BX51, America, Centre Valley PA) for further qualitative pathological studies at 400X magnification ( 16 ).…”

Section: Methodsmentioning

confidence: 99%

A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients

Zandi,

Shojaeian,

Abbasvandi

et al. 2023

Front. Med.

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BackgroundCorrelative interactions between electrical charges and cancer cells involve important unknown factors in cancer diagnosis and treatment. We previously reported the intrinsic suppressive effects of pure positive electrostatic charges (PEC) on the proliferation and metabolism of invasive cancer cells without any effect on normal cells in cell lines and animal models. The proposed mechanism was the suppression of pro-caspases 3 and 9 with an increase in Bax/Bcl2 ratio in exposed malignant cells and perturbation induced in the KRAS pathway of malignant cells by electrostatic charges due to the phosphate molecule electrostatic charge as the trigger of the pathway. This study aimed to examine PECs as a complementary treatment for patients with different types of solid metastatic tumors, who showed resistance to chemotherapy and radiotherapy.MethodsIn this study, solid metastatic tumors of the end-stage patients (n = 41) with various types of cancers were locally exposed to PEC for at least one course of 12 days. The patient’s signs and symptoms, the changes in their tumor size, and serum markers were followed up from 30 days before positive electrostatic charge treating (PECT) until 6 months after the study.ResultsEntirely, 36 patients completed the related follow-ups. Significant reduction in tumor sizes and cancer-associated enzymes as well as improvement in cancer-related signs and symptoms and patients’ lifestyles, without any side effects on other tissues or metabolisms of the body, were observed in more than 80% of the candidates.ConclusionPECT induced significant cancer remission in combination with other therapies. Therefore, this non-ionizing radiation would be a beneficial complementary therapy, with no observable side effects of ionizing radiotherapy, such as post-radiation inflammation.

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Section: Methodsmentioning

confidence: 99%

A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients

Zandi,

Shojaeian,

Abbasvandi

et al. 2023

Front. Med.

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“…They consist of one or more graphene sheets rolled into a continuous cylindrical structure with closed ends and high tensile strength along the axial direction. CNTs have infinite commercial value due to their excellent mechanical, thermal, chemical, and electrical properties, which make them ideal for use in new gas sensors, enzyme biosensors, voltammetry, DNA probes, photocatalysts, adsorbent membranes, batteries, hydrogen storage devices, fuel cells, and biomedical applications . Besides, CNTs have unique antibacterial and antifungal properties due to their electrostatic repulsion, oxidative stress, and membrane damage, − making them attractive nanofillers for active, reinforced, and intelligent packaging materials in food applications.…”

Section: Emerging Nanoparticlesmentioning

confidence: 99%

Emerging Nanoparticles in Food: Sources, Application, and Safety

Chen

Guo

Zhang

et al. 2023

J. Agric. Food Chem.

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Nanoparticles (NPs) are small-sized, with high surface activity and antibacterial and antioxidant properties. As a result, some NPs are used as functional ingredients in food additives, food packaging materials, nutrient delivery, nanopesticides, animal feeds, and fertilizers to improve the bioavailability, quality, and performance complement or upgrade. However, the widespread use of NPs in the industry increases the exposure risk of NPs to humans due to their migration from the environment to food. Nevertheless, some NPs, such as carbon dots, NPs found in various thermally processed foods, are also naturally produced from the food during food processing. Given their excellent ability to penetrate biopermeable barriers, the potential safety hazards of NPs on human health have attracted increased attention. Herein, three emerging NPs are introduced including carbon-based NPs (e.g., CNTs), nanoselenium NPs (SeNPs), and rare earth oxide NPs (e.g., CeO 2 NPs). In addition, their applications in the food industry, absorption pathways into the human body, and potential risk mechanisms are discussed. Challenges and prospects for the use of NPs in food are also proposed.

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“…Au nanocages (AuNCs) coupled with aminated MWCNT (MWCNT-NH2) was used to form a AuNCs/MWCNT-NH2 nanostructure-based SPCE biosensor with good sensitivity and stability given its high surface area, superior conductivity, and excellent biocompatibility. Meanwhile, Zandi et al [83] developed a nanoengineered platinum (Pt) needle electrode to detect reductions in the lipid content of lymph nodes (LNs), which results from fatty acid metabolism by invasive cancer cells. In the mentioned study, the highly conductive and superhydrophobic MWCNTs were used to improve the interactive surface between the Pt electrodes and the lipidic contents of the LNs.…”

Section: Carbon Nanotubesmentioning

confidence: 99%

Advances in Functionalized Nanomaterial‐incorporated Biosensing Platforms for Detecting Cancer Biomarkers during Biopsies

et al. 2023

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Sensors incorporating nanomaterials are being studied with great interest in the field of diagnostics given their high‐sensitivity and accuracy due to the unique advantages of nanomaterials. Cancer is one of the leading causes of death in humans, with its early detection significantly reducing the risk of death and improving treatment prognosis. The gold standard for the early diagnosis of cancers is pathological and genetic analysis of tumor biopsy specimens. Unfortunately, standardization of techniques for separating and quantifying biomarkers from tumor biopsies requires more sensitive, accurate, and rapid early detection techniques. The development of biosensing platforms utilizing various functional nanomaterials is expected to realize the isolation and detection of biomarkers, thereby enabling rapid and accurate early cancer diagnosis. Therefore, this review aims to explore cutting‐edge nanomaterials that fall within the scope of highly sensitive analytical technology biosensor platforms to introduce the transducer platform of biosensing systems using functionalized nanomaterials for the selective recognition and detection of signal‐specific cancer biomarkers. It will pave the way for highly precise cancer detection, providing a unique means to carefully monitor the different types of biopsy sample of patients.

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The design and fabrication of nanoengineered platinum needles with laser welded carbon nanotubes (CNTs) for the electrochemical biosensing of cancer lymph nodes

Abstract: A new biosensor for detecting cancer lymph nodes was developed based on the electrochemical tracing of fatty acid oxidation. The sensor needles were decorated with superhydrophobic multi-walled carbon nanotubes using laser irradiation nano-welding.

Cited by 8 publications

References 20 publications

A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients

A human pilot study on positive electrostatic charge effects in solid tumors of the late-stage metastatic patients

Emerging Nanoparticles in Food: Sources, Application, and Safety

Advances in Functionalized Nanomaterial‐incorporated Biosensing Platforms for Detecting Cancer Biomarkers during Biopsies

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