This Thesis focuses on the history and development of the topography, layout, and facilities of the ancient port of Seville, which is located in the lower Guadalquivir River Basin. From a maritime archaeology perspective, it combines terrestrial and maritime archaeological evidence, literary and epigraphic material, as well as palaeo-geomorphological and palaeo-environmental studies. This Thesis is a longue durée or diachronic study ranging between the 1 st century BC and the 13 th century AD. The Thesis is divided into three main historical periods, and in addition to the port itself, studies the palaeo-geomorphology and palaeo-hydrology of the Guadalquivir River, as well as of the palaeo-climatology of the region during each of these eras.