The Design and Performance of an Instrumentation System for Aqueous Film Coating in an Industrial Tablet Coating Machine

Cole, Graham C.; May, G.S.; Neale, P. J.; Ridgway, K.

doi:10.3109/03639048309042833

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…When the process air volume increased, the degree of coating material loss also increased. According to a previous study, a large amount of air was drawn into the pan causing dis-placement of the spray and turbulence within the pan and resulted in poorly coated tablets and a large amount of coating deposited on the pan wall [1]. The coating liquid may dry prematurely in the air stream and be lost in the exhaust air instead of being transferred to the tablets [10].…”

Section: Influence Of Process Air Flow Rate On the Coating Processmentioning

confidence: 99%

“…The inlet air flow rate influenced the coating process, as described above, and the subsequent quality of the coated tablets ( Figure 10, Table 5) [1]. With increasing process air volume, the evaporative capacity of the coating process increases and the drying of the tablet surface should become more efficient [9,10].…”

Section: Influence Of Process Air Flow Rate On the Film Propertiesmentioning

confidence: 99%

“…The effects of process conditions of a side-vented pan coater are not very well characterized or understood, probably because of the lack of effective instrumentation systems. Only a few previous reports have been published on the topic [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…One of the most important tasks during film coating is to control and measure the critical process parameters [1,3]. If the process conditions during the film coating were better characterized, more satisfactory coating results could be achieved.…”

Section: Introductionmentioning

confidence: 99%

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Development of an automation system for a tablet coater

et al. 2002

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An instrumentation and automation system for a side-vented pan coater with a novel air-flow rate measurement system for monitoring the film-coating process of tablets was designed and tested. The instrumented coating system was tested and validated by film-coating over 20 pilot-scale batches of tablets with aqueous-based hydroxypropyl methylcellulose (HPMC). Thirteen different process parameters were continuously measured and monitored, and the most significant ones were logged for analysis. Laser profilometry was used to measure the surface roughness of the coated tablets. The instrumentation system provided comprehensive and quantitative information on the process parameters monitored. The measured process parameters and the responses of the film-coated tablet batches showed that the coating process is reproducible. The inlet air-flow rate influenced the coating process and the subsequent quality of the coated tablets. Increasing the inlet flow rate accelerated the drying of the tablet surface. At high inlet flow rate, obvious film-coating defects (ie, unacceptable surface roughness of the coated tablets) were observed and the loss of coating material increased. The instrumented and automated pan-coating system described, including historical data storage capability and a novel air-flow measurement system, is a useful tool for controlling and characterizing the tablet film-coating process. Monitoring of critical process parameters increases the overall coating process efficiency and predictability.

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Section: Influence Of Process Air Flow Rate On the Coating Processmentioning

confidence: 99%

Section: Influence Of Process Air Flow Rate On the Film Propertiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of an automation system for a tablet coater

et al. 2002

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“…Potential critical process parameters (CPPs) of the film-coating process include: spray rate, atomization and pattern air, inlet air flow, inlet and outlet air temperature and pan speed. The inlet air flow [2] and temperature are important process parameters which contribute to the drying conditions inside the coating pan. High inlet air temperature increases the drying efficiency of the aqueous film-coating process [12], but this could also result in a loss of coating efficiency [14].…”

Section: Introductionmentioning

confidence: 99%

Optimization Study of Aqueous Film-Coating Process in the Industrial Scale Using Design of Experiments

TOSHEV¹

2023

FARMACIA

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Experimental design approach has been used for optimization of film-coating phase of the immediate release tablets manufacturing process in order to evaluate the effects of the potential critical process parameters (CPPs) and define the optimal operating conditions. Optimization was performed during the transfer of the process on a film-coating machine for pilot and industrial scale production. Immediate release ready-to-use coating system Opadry ® White was used as the coating. Central Composite Orthogonal design with 17 coating runs of size of 103000 pcs was used for the study. The ranges of film-coating process parameters: inlet air flow, inlet air temperature and spray rate for the spraying stage of the coating process were optimized and the effects on: hardness, disintegration time, coating defects, coating efficiency and coating time were evaluated. The results showed that among the process parameters, the spray rate had the highest significant effect on all responses. The inlet air temperature showed a significant effect on the disintegration time. Interaction effects of the spray rate with the inlet air flow were found to be significant for the coating efficiency and disintegration time. Target values and sweet spot area were set for the parameters of the process in order to gain results with fastest disintegration time, highest coating efficiency, lowest number of coating defects, fastest coating time and hardness within the predetermined acceptance criteria. RezumatAbordarea prin design experimental a fost utilizată pentru optimizarea fazei de acoperire în procesul de fabricație a comprimatelor cu eliberare imediată, pentru evaluarea efectelor potențialilor parametri critici ai procesului (CPP) și definirea condițiilor optime de funcționare. Optimizarea a fost efectuată în timpul transferului procesului folosind un echipament de acoperire pentru producție pilot și industrială. Sistemul de acoperire cu eliberare imediată a fost Opadry ® White. Pentru studiu a fost utilizat un design ortogonal central compozit cu 17 serii de acoperire cu dimensiunea de 103000 buc. Au fost optimizați parametrii procesului de acoperire cu film: debitul de aer de admisie, temperatura aerului de intrare și rata de pulverizare pentru etapa de pulverizare a procesului de acoperire și au fost evaluate efectele asupra: durității, timpului de dezintegrare, defectelor de acoperire, eficienței acoperirii și timpului de acoperire. Rezultatele au arătat că dintre parametrii procesului, rata de pulverizare a avut cel mai semnificativ efect asupra tuturor răspunsurilor. Temperatura aerului de intrare a arătat un efect important asupra timpului de dezintegrare. Efectele de interacțiune ale vitezei de pulverizare cu fluxul de aer de intrare s-au dovedit a fi semnificative pentru eficiența acoperirii și timpul de dezintegrare. Valorile țintă și aria punctului favorabil au fost stabilite pentru parametrii procesului, pentru a obține rezultate cu cel mai rapid timp de dezintegrare, cea mai mare eficiență de acoperire, cel mai mic număr de de...

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3 Processing and Equipment Considerations for Aqueous Coatings

Hadfield¹

2016

Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms

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The Design and Performance of an Instrumentation System for Aqueous Film Coating in an Industrial Tablet Coating Machine

Cited by 5 publications

References 4 publications

Development of an automation system for a tablet coater

Development of an automation system for a tablet coater

Optimization Study of Aqueous Film-Coating Process in the Industrial Scale Using Design of Experiments

3 Processing and Equipment Considerations for Aqueous Coatings

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