Background:In lower-and middle-income countries across Asia there has been a rapid expansion and uptake of percutaneous coronary intervention (PCI). However, there has been limited routine collection of related data, particularly around quality, safety and cost. The aim of this study was to assess the viability of implementing routine collection of PCI data in a registry at a leading hospital in Hanoi, Vietnam. Method: A Vietnamese data collection form and collection strategy were developed in collaboration with the Vietnam National Heart Institute. Information on patient characteristics, treatments, and outcomes was collected through direct interviews using a standardised form and medical record abstraction, while PCI data was read and coded into paper forms by interventional cardiologists. Viability of the registry was determined by four main factors: 1) being able to collect a representative sample; 2) quality of data obtained; 3) costs and time taken for data collection by hospital staff; and 4) level of support from key stakeholders in the institute. Results: Between September 2017 and May 2018, 1,022 patients undergoing PCI were recruited from a total of 1,041 procedures conducted during that time frame. The estimated mean time to collect information from patients before discharge was 60 minutes. Of the collected data fields, 98% were successfully completed. Most hospital staff surveyed indicated support for the continuation of the activity following the implementation of the pilot study. Conclusions: The proposed methodology for establishing a PCI registry in a large hospital in Vietnam produced high quality data and was considered worthwhile by hospital staff. The model has the potential opportunity for replication in other cardiac catheterisation sites, leading to a national PCI registry in Vietnam.Coronary heart disease (CHD) is consistently the leading cause of death worldwide, responsible for approximately 16.6% of total deaths in 2016 and places a large economic burden on the population [1,2]. Since its inception in 1977, percutaneous coronary intervention (PCI) has been recognised as a valuable procedure for treating CHD patients and has become a common part of routine practice worldwide [3,4]. The Asia-Pacific region is home to nearly 60% of the world's population, where CHD is now a leading cause of mortality [5,6] and the development of PCI registries is of growing interest [7][8][9]. As a clinical quality registry, a PCI Education in Therapeutics. He is a cardiovascular epidemiologist and clinical trialist with a specific interest in quality improvement and outcomes research. He holds a NHMRC Senior Research Fellowship and has had continual NHMRC research funding since 1997. He has published more than 250 papers with over 6785 citations (Google Scholar H-index 41). Over the past 5 years (from 2009), he has received 17 peer reviewed grants as a Chief Investigator from National and International funding agencies totalling over $70M.