The design of fluorescein–ferrocene derivatives as HOCl-triggered turn-on fluorescent probes and anticancer prodrugs

Wang, Ruiqi; Zhou, Tong; Li, Aimin; Qu, Jian; Zhang, Xin; Zhu, Xiangfeng; Jing, Su

doi:10.1039/d2dt02198f

Cited by 5 publications

(2 citation statements)

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“…High concentrations of ROS, [ 11 ] especially HOCl, [ 12 ] are a critical feature of solid tumors and are used as a typical trigger to activate drug platforms for cancer therapy. [ 13 ] Given that MB has reliable fluorescence properties, the fluorescence intensity of the released MB was considered to guide the HOCl‐response behavior in vivo and in vitro. [ 14 ] First, cancerous‐cell fluorescence imaging experiments in vitro were conducted to analyze the cellular uptake and intracellular activation behavior of this platform (10 µM) using flow cytometry (FCM) and confocal laser scanning microscopy (CLSM).…”

Section: Resultsmentioning

confidence: 99%

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Wang,

Lu,

Song

et al. 2024

Advanced Science

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Coloading adjuvant drugs or biomacromolecules with photosensitizers into nanoparticles to enhance the efficiency of photodynamic therapy (PDT) is a common strategy. However, it is difficult to load positively charged photosensitizers and negatively charged adjuvants into the same nanomaterial and further regulate drug release simultaneously. Herein, a single‐component dual‐functional prodrug strategy is reported for tumor treatment specifically activated by tumor microenvironment (TME)‐generated HOCl. A representative prodrug (DHU‐CBA2) is constructed using indomethacin grafted with methylene blue (MB). DHU‐CBA2 exhibited high sensitivity toward HOCl and achieved simultaneous release of dual drugs in vitro and in vivo. DHU‐CBA2 shows effective antitumor activity against lung cancer and spinal metastases via PDT and cyclooxygenase‐2 (COX‐2) inhibition. Mechanistically, PDT induces immunogenic cell death but stimulates the gene encoding COX‐2. Downstream prostaglandins E2 and Indoleamine 2,3 dioxygenase 1 (IDO1) mediate immune escape in the TME, which is rescued by the simultaneous release of indomethacin. DHU‐CBA2 promotes infiltration and function of CD8+ T cells, thus inducing a robust antitumor immune response. This work provides an autoboost strategy for a single‐component dual‐functional prodrug activated by TME‐specific HOCl, thereby achieving favorable tumor treatment via the synergistic therapy of PDT and a COX‐2 inhibitor.

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Section: Resultsmentioning

confidence: 99%

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Wang,

Lu,

Song

et al. 2024

Advanced Science

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“…28 Ferrocene derivatives, celebrated for their unique reversible redox traits, have found wide acceptance as emission quenchers in FL and ECL sensors. 29,30 Recognizing the electron limitation in ferrocene led to the evolution of bisferrocene, a dual ferrocene-unit structure that bolsters quenching efficiency and detection range. 31 This research pioneers the utilization of RuMOFNSs' distinct optical attributes and bisferrocene's unparalleled quenching proficiency.…”

Section: Introductionmentioning

confidence: 99%

Dual-mode fluorescence and electrochemiluminescence sensors based on Ru-MOF nanosheets for sensitive detection of apoE genes

Hu,

Cui,

Yin

et al. 2024

J. Mater. Chem. B

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Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

Kondengadan,

Wang

2024

Angewandte Chemie

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Reactive oxygen species (ROS) are critical for cellular signaling. Various pathophysiological conditions are also associated with elevated levels of ROS. Hence, ROS‐sensitive triggers have been extensively used for selective payload delivery. Such applications are predicated on two key functions: (1) a sufficient magnitude of concentration difference for the interested ROS between normal tissue/cells and intended sites and (2) appropriate reaction kinetics to ensure a sufficient level of selectivity for payload release. Further, ROS refers to a group of species with varying reactivity, which should not be viewed as a uniform group. In this review, we critically analyze data on the concentrations of different ROS species under various pathophysiological conditions and examine how reaction kinetics affect the success of ROS‐sensitive linker chemistry. Further, we discuss different ROS linker chemistry in the context of their applications in drug delivery and imaging. This review brings new insights into research in ROS‐triggered delivery, highlights factors to consider in maximizing the chance for success and discusses pitfalls to avoid.

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The design of fluorescein–ferrocene derivatives as HOCl-triggered turn-on fluorescent probes and anticancer prodrugs

Abstract: Overexpressed HOCl in tumor can behave as an activator for imaging-guided precision therapy. Herein, a new kind of HOCl-activated molecular platforms has been developed aiming at the integration of detection,...

Cited by 5 publications

References 44 publications

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Single‐Component Dual‐Functional Autoboost Strategy by Dual Photodynamic and Cyclooxygenase‐2 Inhibition for Lung Cancer and Spinal Metastasis

Dual-mode fluorescence and electrochemiluminescence sensors based on Ru-MOF nanosheets for sensitive detection of apoE genes

Quantitative Factors Introduced in the Feasibility Analysis of Reactive Oxygen Species (ROS)‐Sensitive Triggers

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