The design of new molecular "light switches" for DNA

Zou, Xiaohua; Ye, Bao‐Hui; Li, Hong; Zhang, Qianling; Chao, Hui; Liu, Jingang; Ji, Liang‐Nian; Li, Xiaoyuan

doi:10.1007/s007750000183

Cited by 135 publications

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“…We have been carrying out a systematic study of the interactions of Ru II -polypyridine complexes with DNA, and one of our aims is to find a sensitive luminescence probe for DNA. In our previous study, the complex [Ru(bpy) 2 ,10]phenanthroline) was developed to act as a molecular light switch for DNA in aqueous solution [24]; three other complexes, [Ru(phen) 2 ,10] phenanthroline) are also found to possess similar properties [32]. These results indicated that a complex whose luminescence intensity correlates well with the polarity of the medium might serve to explore the DNA -complex interaction.…”

Section: (Dppz)]mentioning

confidence: 90%

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

Gao

Chao

2008

Chemistry & Biodiversity

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The interaction of ruthenium(II)-polypyridyl complexes with DNA has attracted considerable interests during the past two decades. This paper presents some recent progresses in our laboratory on the interaction of Ru(II)-polypyridyl complexes with DNA. The first part describes the effect of modulating the intercalative ligand on the DNA-binding behaviors of the complexes, such as DNA-binding affinity, DNA-binding enantioselectivity, DNA molecular 'light switch' effect, and DNA sequence selectivity. The second part focuses on the DNA photocleavage by the complexes and its mechanism. In the final part, we discuss the topoisomerase inhibition and its mechanism, as well as the antitumor activity of the Ru(II)-polypyridyl complexes.

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Section: (Dppz)]mentioning

confidence: 90%

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

Gao

Chao

2008

Chemistry & Biodiversity

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“…These studies are closely related to the replication of DNA in vivo, mutation of genes, and action mechanisms of some DNA-targeted drugs [4][5][6]. Factors that determine the affinity and selectivity in binding of small molecules to DNA would be valuable in the design of new diagnostic and therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Interaction mode between Congo red–Sm(III) complex and herring sperm DNA

Pan

Wang

et al. 2010

Journal of Coordination Chemistry

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Spectroscopic and viscosity methods were applied to investigate the mechanism of interaction between Congo red (CR)-Sm(III) complex and herring sperm DNA by using acridine orange as a spectral probe in Tris-HCl buffer (pH 7.40). The binding ratio of Sm(III)(CR) 3 : DNA is 5 : 1, the apparent molar absorptivity of " Sm(III)(CR)3-DNA is 4.80 Â 10 5 L (mol cm) À1 and the bonding constant of Sm(III)(CR) 3 interacting with DNA is KThe results confirm that the interaction between Sm(III)(CR) 3 complex and DNA is a partial intercalation, and the reaction process is entropy favorable.

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“…Many metal complexes have the potential to be developed into novel probes of DNA structure [1][2][3][4][5], and can be used as mediators of duplex DNA cleavage reactions [6][7][8], as anticancer drugs [9] that control the reproduction of DNA in the body of living organs, as electron acceptors and donors for studying long-range electron transfer through DNA films [10][11][12], as hybridization indicators for DNA electrochemical biosensors [13][14][15][16][17][18][19][20][21], and as agents for DNA emission labels [22], just to name a few. In the last decades increasing efforts have been devoted to studying the interactions of metal complexes with double-stranded DNAs.…”

Section: Introductionmentioning

confidence: 99%

Interactions of polypyridyl cobalt complexes with DNA studied by rotating electrode methods

et al. 2005

J Appl Electrochem

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The interaction of transition metal complexes Co(phen) 2 TATP 3+ , Co(phen) 3 3+ and Co(bpy) 3 3+ (where TATP ¼ 1,4,8,9-tetra-aza-trisphenylene, phen ¼ 1,10-phenanthroline, and bpy=2,2¢-bipyridine) with calf thymus DNA was investigated using the rotating ring-disk electrode technique. The values of the apparent diffusion coefficient and rate constant at the formal potential for reduction of these three polypyridyl cobalt complexes were found to decrease significantly in the presence of DNA as compared with that in the absence of DNA. The formal potentials at which the redox reaction takes place in the absence or presence of DNA were in the order of Co(phen) 2 TATP 3+/2+ > Co(phen) 3 3+/2+ > Co(bpy) 3 3+/2+ . The interaction between the complexes and DNA varied significantly, depending on the nature of ligands. The binding strength of these complexes to DNA was found in the order of Co(phen) 2 TATP 3+ > Co(phen) 3 3+ > Co(bpy) 3 3+ . The interaction modes of the polypyridyl cobalt complexes with DNA were discussed in line of electrochemical observations.

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The design of new molecular "light switches" for DNA

Cited by 135 publications

References 0 publications

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

Interaction mode between Congo red–Sm(III) complex and herring sperm DNA

Interactions of polypyridyl cobalt complexes with DNA studied by rotating electrode methods

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