The design strategy for pillararene based active targeted drug delivery systems

Abstract

This feature article comprehensively summaries three present design strategies for pillararene based active targeted DDSs, and evaluates their performance in tumor therapy application, respective strengths and weaknesses.

Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

“…Since the first report of the preparation and host-guest chemistry of pillar [5]arene by Ogoshi et al in 2008, 42 pillararenes have been developed as versatile scaffolds for the development of bioactive molecular, supramolecular and macromolecular materials. [43][44][45][46][47] Compared with other analogues, pillar [5]arene can be prepared in the highest yield. 42 We thus prepared an imidazolium-appended pillar [5]arene derivative P5A 48 as a decacationic supramolecular crosslinker to co-assemble with hyaluronic acid (HA, average molecular weight: 3000 Da) to afford ionic supramolecular polymers (ISPs).…”

Pillararene‐Based Stimuli‐Responsive Supramolecular Delivery Systems for Cancer Therapy

“…[116,117] Furthermore, developing degradable pillararene-based SDSs consisting of new pillararenes provides a unique perspective to surmount the aforementioned challenges. [17] Overall, although the application of stimuli-responsive pillararene-based SDSs in cancer therapy still faces long-term challenges, the significant advances made to date provide a reference basis for its further use in clinical. With the continuous research on pillararene-based SDSs, the new stimuli-responsive nanoplatforms are expected to be further improved and developed to provide better therapeutic options for cancer patients.…”

“…Notably, the DOI: 10.1002/adma.202313317 pioneering works of pillararenes first reported by Ogoshi and co-workers [14] have attracted tremendous attention in the past fifteen years due to their convenient synthetic routes, high production yields, rigid electron-rich structures, unique host-guest interactions, and tunable cavity sizes, which have been further explored and widely applied in supramolecular chemistry, materials science, and biomedicine. [15][16][17][18][19][20][21] Owing to the tunable noncovalent interactions and diverse functionalization features of pillararene, pillararene-based SDSs, such as single molecule therapeutic agents, host-guest complexes, supramolecular self-assembly, metal/nonmetal nanoparticles, and porous materials, can achieve precise targeted delivery and controlled release via the integration of functional moieties and pillararene-based control components, which is conducive to improving therapeutic efficacy and reducing side effect during tumor therapy. Notably, the dynamic binding modes of pillararenes with functional moieties are one of the most significant merits in the fabrication of smart pillararene-based SDSs.…”

Synergizing supramolecular chemistry and reverse saturable absorption: exploring pillar[5]arene with metal-complexed ligands

“…Research shows that these compounds have a wide range of applications, especially in the field of supramolecular chemistry, such as in the development of polymeric systems for biomedical applications, 1 host-guest binding properties, 2 and adsorption and separation processes. 3,4 Additionally, they're used in catalysis and sensing applications, 5 and have been modified for specific functions like targeted drug delivery 6 , imaging and utilized in Xenon based MRI applications. 7 Thus, the study of pillar [5]arenes, has garnered significant interest due to its unique host-guest interaction capabilities and structural versatility.…”