The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants

Walker, Jennifer N.; Pinkner, Chloe L.; Pinkner, Jerome S.; Hultgren, Scott J.; Myckatyn, Terence M.

doi:10.1097/gox.0000000000002037

Cited by 28 publications

(25 citation statements)

References 56 publications

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“…Furthermore, the in vitro assay setup in this study is a simplified 2-dimensional testing platform, which employed polystyrene instead of silicone surfaces. The role of surface texturization as well as its effects on protein binding have been evaluated in various studies 32 , 33 , 54 and suggest that the presence of proteins such as fibrinogen and type I or type III collagen may have a pronounced effect on bacterial biofilm formation. In our study, data suggest that interaction of serum proteins with PI could negatively impact its efficacy.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation—Part 2: Efficacy Against Biofilm-Associated Bacteria

Jewell¹,

Bionda²,

Moran³

et al. 2021

Aesthetic Surgery Journal

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Background Biofilm-associated bacteria have been observed in both breast implant revision and tissue expander-implant exchange surgeries. The utilization of antimicrobial solutions in breast surgery, especially those containing triple antibiotics (TAB) and/or 10% povidone-iodine (PI), may help reduce existing biofilm-associated bacteria, which is particularly important in a mature breast pocket that may contain residual bacteria from a previously colonized implant surface or, theoretically, bacteria that may arrive postoperatively through hematogenous spread. Objectives A series of in vitro assessments was performed to evaluate the antimicrobial utility of TAB and PI, either alone or in combination, against preformed biofilm-associated bacteria. Methods Preformed biofilm-associated gram-positive and gram-negative bacterial strains were exposed to TAB and PI ± TAB for up to 30 minutes in a bacterial time-kill assay. Efficacy of various dilutions of PI and the effects of serum protein on PI efficacy were also investigated. Results TAB was ineffective at the timeframes tested when utilized alone; when utilized in conjunction with PI, significant log reduction of all biofilm-associated bacterial species tested was achieved when treated for at least 5 minutes. PI alone at a concentration of 25% or higher was also effective, although its efficacy was negatively affected by increasing serum protein concentration only for Staphylococcus epidermidis. Conclusions Our data indicate that PI-containing solutions significantly reduce biofilm-associated bacteria, suggesting potential utility for breast pocket irrigation during revision or exchange surgeries. Care should be taken to minimize excessive dilution of PI to maintain efficacy.

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Section: Discussionmentioning

confidence: 99%

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation—Part 2: Efficacy Against Biofilm-Associated Bacteria

Jewell¹,

Bionda²,

Moran³

et al. 2021

Aesthetic Surgery Journal

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“…Breast augmentation is one of the most frequent cosmetic surgical procedures practiced worldwide and can lead to several complications, capsular contracture being the most common one (Rieger et al, 2013;Cook et al, 2020). Bacterial growth, and subsequent biofilm formation, is one of the main risk factors for capsular contracture (Dancey et al, 2012;Ajdic et al, 2016;Walker et al, 2019). It has been suggested that chronic biofilm infection of breast implants may be implicated in the development of breast implant-associated lymphoma (Hu et al, 2015;Hu et al, 2016).…”

Section: Microbiota Of the Breast Tissue Of Non-lactating Womenmentioning

confidence: 99%

The Microbiota of the Human Mammary Ecosystem

Fernández

Pannaraj

Rautava

et al. 2020

Front. Cell. Infect. Microbiol.

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Human milk contains a dynamic and complex site-specific microbiome, which is not assembled in an aleatory way, formed by organized microbial consortia and networks. Presence of some genera, such as Staphylococcus, Streptococcus, Corynebacterium, Cutibacterium (formerly known as Propionibacterium), Lactobacillus, Lactococcus and Bifidobacterium, has been detected by both culture-dependent and culture-independent approaches. DNA from some gut-associated strict anaerobes has also been repeatedly found and some studies have revealed the presence of cells and/or nucleic acids from viruses, archaea, fungi and protozoa in human milk. Colostrum and milk microbes are transmitted to the infant and, therefore, they are among the first colonizers of the human gut. Still, the significance of human milk microbes in infant gut colonization remains an open question. Clinical studies trying to elucidate the question are confounded by the profound impact of non-microbial human milk components to intestinal microecology. Modifications in the microbiota of human milk may have biological consequences for infant colonization, metabolism, immune and neuroendocrine development, and for mammary health. However, the factors driving differences in the composition of the human milk microbiome remain poorly known. In addition to colostrum and milk, breast tissue in lactating and non-lactating women may also contain a microbiota, with implications in the pathogenesis of breast cancer and in some of the adverse outcomes associated with breast implants. This and other open issues, such as the origin of the human milk microbiome, and the current limitations and future prospects are addressed in this review.

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“…7,8 A esto se añade la reciente asociación con el linfoma anaplásico de células gigantes, se han reportado hasta ahora 600 casos en todo el mundo, los cuales tienen como características la aparición a 10 años del procedimiento de colocación y la probable etiología de contaminación del implante y contracción capsular, lo que propicia un entorno inflamatorio al implante. 9,10 Basándose en literatura reciente, se han establecido cuatro teorías para la formación de dobles cápsulas en los implantes mamarios: la primera hipótesis se basa en el movimiento de la prótesis dentro de un bolsillo de tejido de gran tamaño; los macro y micro movimientos del implante evitan la adhesión de la superficie texturizada del implante a los tejidos circundantes. 11 La segunda hipótesis sugiere una etiología mecánica mediante la cual el esfuerzo de cizallamiento aplicado al complejo de la cápsula protésica aleja la prótesis de la cápsula; esta separación conduce a la creación posterior de una nueva capa interna de cápsula en contacto directo con la prótesis.…”

Section: Discussionunclassified

Fenómeno de doble cápsula bilateral en mamoplastia de aumento

Hernández¹,

Cruz²,

Villanueva³

et al. 2020

Anales Médicos De La Asociación Médica Del Centro Médico ABC

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La mamoplastia con la utilización de implantes mamarios es un procedimiento cada vez más frecuente, tanto en cirugía estética para mamoplastia de aumento como para reconstrucción oncológica después de mastectomía total. El aumento en la realización de este procedimiento ha traído consigo un incremento proporcional de las complicaciones postquirúrgicas asociadas a éste. Aunque las complicaciones asociadas con la mastoplastia con colocación de implantes son diversas, el fenómeno de doble cápsula es una complicación particularmente infrecuente, la cual en los últimos años ha cobrado un interés importante dentro de la cirugía plástica. Una búsqueda intencionada en las principales bases de datos médicas confirma lo inusual del caso, al encontrar no más de 40 artículos publicados. En el presente artículo presentamos el caso del hallazgo de fenómeno de doble cápsula bilateral en una paciente con implantes mamarios texturizados (BIOCELL MT McGhan ST-110) de localización retromuscular con estado postquirúrgico de ocho años, en una mujer de 46 años aparentemente sana. En él se observa una doble cápsula fibrosa, una íntimamente adherida al implante y otra más holgada recubriendo ambas estructuras. Así como un análisis de la literatura que ha sido publicada en los últimos años, haciendo enfoque en la fisiopatología y las teorías aceptadas en la etiología de este fenómeno.

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The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants

Abstract: Supplemental Digital Content is available in the text.

Cited by 28 publications

References 56 publications

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation—Part 2: Efficacy Against Biofilm-Associated Bacteria

In Vitro Evaluation of Common Antimicrobial Solutions Used for Breast Implant Soaking and Breast Pocket Irrigation—Part 2: Efficacy Against Biofilm-Associated Bacteria

The Microbiota of the Human Mammary Ecosystem

Fenómeno de doble cápsula bilateral en mamoplastia de aumento

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