The determination of a reference range for new platelet parameters produced by the Bayer ADVIA^TM 120 full blood count analyser

Abstract

One hundred and twenty-two samples from normal volunteers were processed for full blood count analysis through the Bayer ADVIA120. The samples were simultaneously tested using the marker CD62P to establish the absence of platelet activation. Samples were tested at two time intervals, 20 min and 3.5 h, to simulate the testing practice for routine and urgent samples in our laboratory. From these data the mean and reference ranges, with 95% confidence limits, for platelet parameters were calculated for the ADVIA120. The time difference for some platelet parameters was significant. Hence two ranges have been reported. The age or smoking habit of the volunteer did not significantly affect platelet results but there was a statistically significant sex difference in some platelet parameters.

Platelet indices- evaluation of their diagnostic role in pediatric thrombocytopenias (one year study)

“…In this study, it was found that the platelet-derived indices of mean platelet volume, platelet distribution width, and platelet-large cell ratio show significantly high values for cases of ITP compared with hypoproductive type. The sensitivity, specificity, positive p-value, and the negative p value of the platelet-derived indices were appropriate for differentiating between thrombocytopenias due to platelet destruction (ITP) and low platelet production as was observed in studies carried out by Bowles et al; 10 Lee WS; 11 Briggs C; 12 Farias; 13 Brummitt; 14 Lanzkowsky P. 15 In the present study average MPV for Controls was 9. In the present study, the P-LCR was significantly higher in ITP patients compared with the control group and significantly lower in hypoproductive thrombocytopenia patients compared with the control group.…”

High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes

“…Because of our original inclusion criteria (patients who underwent PCI and for whom hsCRP levels and MPV were measured), a selection bias is possible. Moreover, MPV increases with increasing storage duration in EDTA, and the outcomes become more and more untrustworthy after 4 h [35,36]. However, the MPV Outcome prediction by hsCRP and MPV after PCI Moon et al 75 Log-rank < 0.0001…”

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