The Determination of Absorption Rates from Rat Muscles: an Experimental Approach to Kinetic Descriptions

Drug Elimination Kinetics Following Subconjunctival Injection Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging

“…Our results also showed that there was no significant difference in clearance rate between the 200 and 600 ml injection volumes. Previous studies using intramuscular injections reported a higher rate of absorption of hydrophilic drugs when the compounds were administered in smaller injection volumes (26,27). This is expected as a high interface area to injection volume ratio increases the drug absorption rate (28,29).…”

Peripheral α2-adrenoceptor antagonism affects the absorption of intramuscularly coadministered drugs

“…The postural muscles usually have more abundant blood flow that hastens the drug absorption compared to non-postural muscles (Baxter & Evans 1973;Benet et al 2011). In addition, the amount of perimuscular fat or intermuscular fascial planes can reduce the rate of drug absorption (Sund & Schou 1964). The epaxial muscle group contains numerous fascial planes and this may have been one of the factors causing the wide variability in our results (Dyce et al 2002).…”

Absorption of Atropine: Anticholinergic Agents as Inhibitors of Absorption from Muscles

“…The clearance rate (relative clearance) for atropine decreases gradually with increasing concentrations of the drug over a certain threshold level (about 0.5 mglml). This is in contrast to the clearance of sucrose, which is independent of concentration over a wide range (SUND & SCHOU 1964).…”

“…The absorption experiments were performed as described in another paper (SUND & SCHOU 1964). Briefly, 16 p1 of a solution containing the labelled test substance, with sodium chloride added to isotonicity, were injected into the exposed m. extensor quadriceps femoris of the rats anaesthetized with mebumal i.p.…”