The determination of enantiomeric composition of methamphetamine by 1H-NMR spectroscopy

Kram, Theodore C.; Lurie, Ira S.

doi:10.1016/0379-0738(92)90119-h

Cited by 16 publications

(11 citation statements)

References 28 publications

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“…Other techniques such as UV‐vis absorbance spectrometry (Kubo et al, 1996), circular dichroism (Fleischhauer et al (1997), infrared transmission spectrometry (Chappell, 1997), and NMR spectroscopy (Kram & Lurie, 1992) have also been used for enantiomeric discrimination in liquid phase. In absorbance spectrometry, chiral discrimination of two enantiomers occurs through the measurement of the absorption spectrum of their complexes with a chiral reference (host‐guest systems).…”

Section: Chiral Clustersmentioning

confidence: 99%

Chiral recognition by mass‐resolved laser spectroscopy

Speranza

Satta

Piccirillo

et al. 2004

Mass Spectrometry Reviews

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Chiral recognition is a fundamental phenomenon in life sciences, based on the enantioselective complexation of a chiral molecule with a chiral selector. The diastereomeric aggregates, formed by complexation, are held together by a different combination of intermolecular forces and are therefore endowed with different stability and reactivity. Determination of these forces, which are normally affected in the condensed phase by solvent and supramolecular interactions, requires the generation of the diastereomeric complexes in the isolated state and their spectroscopic investigation. This review deals with chiral recognition in the gas phase through the application of laser-resolved mass spectrometric techniques (R2PI-TOF and RET-MS). The measurement of the fragmentation thresholds of diastereomeric clusters by these techniques allows the determination of the nature of the intrinsic interactions, which control their formation and affect their stability and reactivity.

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Section: Chiral Clustersmentioning

confidence: 99%

Chiral recognition by mass‐resolved laser spectroscopy

Speranza

Satta

Piccirillo

et al. 2004

Mass Spectrometry Reviews

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show abstract

“…All compounds have been characterized by IR, 1 H NMR, 13 C NMR, MS, and elemental analysis. The 1 H and 13 C NMR, data showed that these compounds exist in a cone conformation.…”

Section: Discussionmentioning

confidence: 99%

“…Several methods have already been developed for enantiometric purity determination by using the specific rotation, 6 circular dichroism, 7 capillary electrophoresis, 8 and separation techniques, including liquid and gas chromatography. 9 Other techniques such as polarimetry, absorbance spectrometry, 10 infrared transmission spectrometry, 11 X-ray anomalous scattering, 12 and NMR spectrometry 13 have also been used.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel chiral chromogenic calix[4](azoxa)crown-7

Sirit

Karaküçük

Memon

et al. 2004

Tetrahedron: Asymmetry

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“…2.3 Hz, 2H, ArH), 7.64 (dd, J = 3.2; 2.3 Hz, 2H, ArH), 7.25-7.12 (m, 5H, ArH), 3.88-3.84 (m, 1H, NCH 2 CHOH), 3.74-3.64 (m, 2H, NCH 2 CH and NCHCH 3 ), 3.61 (dd, J = 5.1; 9.0 Hz, 1H, NCH 2 CH), 2.58 (dd, J = 3.9; 8.6 Hz; 1H, NHCH 2 CH), 2.37 (dd, J = 5.5; 7.0 Hz; 1H, NHCH 2 CH), 2.22-2.06 (m, 2H, NH and OH), 1.29 (d, J = 6.6 Hz, 3H, NHCHCH 3 ); 13 …”

Section: Synthesesmentioning

confidence: 99%