The Determination of N-Methylformamide and N-Methylacetamide in Urine

Barnes, John; Henry, Norman W.

doi:10.1080/0002889748507009

Cited by 21 publications

(4 citation statements)

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“…During gas chromatographic analysis, DMF-OH and NMF-OH are transformed into NMF as a result of heating. For this reason, NMF is used for metabolic investigations and biological monitoring (Barnes and Henry 1974;Kawai et al 1992;Krivanek et al 1978;Lauwerys et al 1980;Max®eld et al 1975;Mraz and Nahova 1992b;Mraz and Turecek 1987;Santoni et al 1992).…”

Section: Introductionmentioning

confidence: 99%

N , N- Dimethylformamide - influence of working conditions and skin penetration on the internal exposure of workers in synthetic textile production

Wrbitzky

Angerer

1998

International Archives of Occupational and Environmental Health

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Section: Introductionmentioning

confidence: 99%

N , N- Dimethylformamide - influence of working conditions and skin penetration on the internal exposure of workers in synthetic textile production

Wrbitzky

Angerer

1998

International Archives of Occupational and Environmental Health

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“…Krivanek et al (1978), using the same method of assay of MF in urine (Barnes and Henry, 1974), have shown that volunteers exposed to concentrations of DMF in air of approximately 10 ppm for six hours daily for five days excreted MF in their urine at a peak rate of about 0-25 pul/h, within three hours of the cessation of exposure each day. The mean MF concentration in urine collected in the first seven hours after exposure was 4-7 ,ul/l, and in 24 hours' urine, 0-73 ,ul/l.…”

Section: Discussionmentioning

confidence: 99%

“…Chemical methods MF in urine was determined by gas chromatography according to the method of Barnes and Henry (1974). The lower limit of detection was 10 ,ul/l.…”

Section: Urine Testingmentioning

confidence: 99%

Dimethylformamide and alcohol intolerance.

Lyle¹,

Spence²,

McKinneley³

et al. 1979

Occupational and Environmental Medicine

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(1977) showed that DMF or disulfiram administered (each in doses of 2 mmol/kg) to rats increased the blood acetaldehyde levels of these animals four-and five-fold respectively in response to ethanol (2 g/kg) given 18, but not three, hours later. An equivalent dose of N-methylformamide (MF) raised blood acetaldehydn levels equally, whether given three or 18 h before ethanol challenge. Eben and Kimmerle (1976) have shown that, in volunteers exposed for two hours to an atmosphere containing 50-80 ppm of DMF, blood DMF concentrations were of the order of 9-9 ,tg/ml and had fallen to undetectable levels within six hours. Blood MF over the same period rose from a mean of 2-5 jug/ml to 3-2 ,ug/ml and was still detectable in traces after 30 h.One hundred and two men, at various times over a period of three years, were engaged in running a chemical plant in which DMF was used as a solvent. Shortly after operations began in early 1974 some of the men reported that their customary

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“…The information on individual worker absorption of the solvent was obtained by collecting pre-and post-shift urine samples from 22 workers and determining the N-methylformamide (NMF) concentrations using Barnes's gas chromatographic method [Barnes and Henry, 1974;Catenacci et al, 1980]. These 22 subjects, all working on the same shift, were considered representative of the entire group of exposed workers.…”

Section: Methodsmentioning

confidence: 99%