The determination of p-ANCA and asca could be useful in differentiating Crohn's disease from ulcerative colitis

Lecis, P.; Germanà, B.; Bertiato, G.; Papa, C.; Galliani, E.; Doglioni, Claudio; Costan, Franco

doi:10.1016/s0016-5085(00)81284-6

Cited by 1 publication

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“…Despite numerous similarities, the two diseases also show significant differences involving their clinical and molecular aspects. To use some examples, inflammatory lesions in UC are situated solely in the colon, spread by continuity, are more rarely associated with complications, and their serological picture shows the predominance of antineutrophil cytoplasmic antibodies (pANCA) [1]. By contrast, CD may involve any segment of the gastrointestinal tract, inflammatory lesions develop segmentally and are often accompanied by abscesses, fistulas and strictures.…”

Section: Introductionmentioning

confidence: 99%

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Serum level of lactadhedrin (MFGE8) in inflamatory bowel disease

Kozioł,

Owczarek,

Cibor

et al. 2023

Folia Medica Cracoviensia

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Objective: Evaluation of serum lactadherin level, its correlation with disease activity and certain biochemical parameters in IBD patients. Methods: The study involved adult IBD patients, comprising 50 with ulcerative colitis (UC), 68 with Crohn’s disease (CD), and 29 healthy controls. Results: The MFGE8 median concentration was significantly higher in UC versus controls (1914.54 vs. 1392.21; p = 0.017), but not in CD. The median MFGE8 levels in UC and CD patient groups didn’t significantly differ. There was a significant inverse correlation between MFGE8 and CRP (r = –0.283; p = 0.044) and fibrinogen (r = –0.362, p = 0.017) in UC. In active UC, MFGE8 median concentration was higher versus controls (1974.36 vs. 1392.21; p = 0.04) and negatively correlated with CRP (r = –0.482; p = 0.005), WBC (r = –0.391; p = 0.027), and fibrinogen (r = –0.473; p = 0.015). Inactive UC showed negative correlation only with fibrinogen (r = –0.567; p = 0.018). No correlations were found with disease activity measured using appropriate scales, age, BMI, or gender. Conclusions: Active UC patients show higher MFGE8 levels. These increase inversely with inflamma-tory markers (CRP, WBC, fibrinogen) in active UC, but not in CD.

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Section: Introductionmentioning

confidence: 99%

“…By contrast, CD may involve any segment of the gastrointestinal tract, inflammatory lesions develop segmentally and are often accompanied by abscesses, fistulas and strictures. The characteristic finding in the serological picture is the predominance of the anti-Saccharomyces cerevisiae antibodies (ASCA) [1].…”

Section: Introductionmentioning

confidence: 99%