The determination of some “toxic” metals in human liver as a guide to normal levels in new zealand

Johnson, Christine A.; Lewin, J F; Fleming, Patricia A.

doi:10.1016/s0003-2670(01)82205-4

Cited by 12 publications

(3 citation statements)

References 2 publications

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“…Some studies have been carried out in which selenium contents in various biological tissues were measured in-vitro from autopsy samples (Johnson and Lewin, 1976;Milman et al,1983;Milman et al, 1986, Aadland et al, 1987Molokhia and Molokhia, 1990;a Chen et al, 1999;b Chen et al, 1999;Hac et al, 2003;Xing et al, 2006). In these studies, specimen samples were extracted by biopsy from living or deceased subjects and were analyzed using different analytical techniques.…”

Section: Rationale Of the Present Studymentioning

confidence: 99%

Feasibility of measuring selenium in humans usingin vivoneutron activation analysis

Tahir

Chettle²,

Byun³

et al. 2015

Physiol. Meas.

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Selenium (Se) is an element that, in trace quantities, plays an important role in the normal function of a number of biological processes in humans. Many studies have demonstrated that selenium deficiency in the body may contribute to an increased risk for certain neoplastic, cardiovascular, osseous, and nervous system diseases including retardation of bone formation. However, at higher concentrations Se is cytotoxic. For these reasons it is desirable to have a means of monitoring selenium concentration in humans.This paper presents the outcome of a feasibility study carried out for measuring selenium in humans using in vivo neutron activation analysis (IVNAA). In this technique a small dose of neutrons is delivered to the organ of interest, the neutrons are readily captured by the target nuclei, and the γ-rays given off are detected outside of the body. For the present study, human hand (bone) tissue equivalent phantoms were prepared with varying amounts of Se. These were irradiated by a low energy fast neutron beam produced by the (7)Li(p,n)(7)Be reaction employing the high beam current Tandetron accelerator. The counting data saved using a 4π NaI(TI) detection system were analyzed. The selenium was detected via the neutron capture reaction, (76)Se(n,γ)(77 m)Se, whereas calcium was detected through the (48)Ca(n,γ)(49)Ca reaction for the purpose of normalization of the Se signals to the calcium signals. From the calibration lines drawn between Se/Ca concentrations and Se/Ca counts ratio, the minimum detection limits (MDLs) were computed for two sets of phantoms irradiated under different irradiation parameters.In this study the optimized MDL value was determined to be 81 ng g(-1) (Se/phantom mass) for an equivalent dose of 188 mSv to the phantom. This MDL was found at least 10 times lower than the reported data on Se concentration measured in bone tissues. It was concluded that the NAA technique would be a feasible means of performing in vivo measurements of selenium in humans. Currently the data on in vivo measurement of selenium in humans are limited; the results of the present study would greatly contribute to the present data.

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Section: Rationale Of the Present Studymentioning

confidence: 99%

Feasibility of measuring selenium in humans usingin vivoneutron activation analysis

Tahir

Chettle²,

Byun³

et al. 2015

Physiol. Meas.

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“…FAAS technique has been successfully used to detect levels of silver in post-mortem human liver; the detection limit for this method was 0.34 µg/g (Johnson 1976). …”

Section: Biological Materialsmentioning

confidence: 99%

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

et al. 2009

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“…These results broadly confirm the more extensive studies in animals (5). The gold levels detected are extremely high, at least as high as the toxic levels of other heavy metals (6), and raise questions about the chemical form, toxicity, and bioavailability of the gold stores built up during therapy.…”

Section: To the Editormentioning

confidence: 99%

Gold levels in kidney, liver, and spleen

Kamel

Brown

Ottaway

et al. 1976

Arthritis & Rheumatism

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The determination of some “toxic” metals in human liver as a guide to normal levels in new zealand

Cited by 12 publications

References 2 publications

Feasibility of measuring selenium in humans usingin vivoneutron activation analysis

Feasibility of measuring selenium in humans usingin vivoneutron activation analysis

A randomized controlled evaluation of absorption of silver with the use of silver alginate (Algidex) patches in very low birth weight (VLBW) infants with central lines

Gold levels in kidney, liver, and spleen

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