The determination of sulphonamides by titration in anhydrous acetic acid solution

Quantitative Estimation of Amine-Cadmium Halide Complexes

“…The pioneer investigations of these workers were followed by intensive theoretical and applied studies of others and as a result nonaqueous titrimetry with perchloric acid has become a widely accepted method for assaying many classes of chemical substances. Strong and wreak organic bases (1, 8, 9, 14, 19, 21, 81), amino alcohols (19), alkylene oxides (8), amino acids and polypeptides (1,11,20, SO), oxazolines (19), tertiary aliphatic and aromatic amines in the presence of primary and secondary amines (1, 8, 12, 82), basic nitrogen compounds in refined aromatic and aliphatic hydrocarbons (83) and in hydrogenated coal oils (34), sulfonamides (81), antihistamines (18), vitamins and related compounds (17,22,24), salts of amines, basic heterocyclic nitrogen and quaternary ammonium compounds (1,8,22), alkali metal salts (15, 16, 21, 23), and salts of organic and inorganic acids (2, 3, 19, 21,23,31) have all been determined by titration with perchloric acid in nonaqueous systems.…”

Acid-Base Titrations in Nonaqueous Solvents

“…Sulfonamides. The behavior of eight sulfonamides when titrated in acetic acids was studied by Tomicek (70). The stronger bases may be titrated with crystal violet as indicator; the weaker ones are best titrated potentiometrically.…”

“…Vibrating platinum electrodes have been used by Harris and Lindsey (27) and by Rosenberg, Perrone, and Kirk (70). Vyakhirev (79) used lead electrodes for the titration of sulfate with lead.…”

“…Methods for acid-base titrations have been reported which employ the following indicators: modified methyl orange (xylene cyanol) (80), methyl red (80, 60), thymol blue (88, 50, 51, 58), methyl violet (21,33,39,77), 1-naphtholbenzein (32, S3, 59, 70), bromocresol yellow' (38), crystal violet (56,59,67,70), phenolphthalein (58), benzyl auramine (59), methyl orange (60), and cresol red (70).…”

“…Two compounds that were known to be of high purity were titrated with the standard acid. The following is a summary of the results: Sodium carbonate was one of the first substances to be used for standardizing nonaqueous acid solutions and still finds wide acceptance (4,36,67,70,77).…”