The determination of tissue perfusion and collateralization in peripheral arterial disease with indocyanine green fluorescence angiography

Zimmermann, Alexander; Roenneberg, Casper; Reeps, Christian; Wendorff, Heiko; Holzbach, T.; Eckstein, H.‐H.

doi:10.3233/ch-2011-1408

Cited by 27 publications

(29 citation statements)

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“…53 The emitted fluorescence was allowed to pass through different filter sets to ensure the NIR images the saturation level of the control cerebral hemisphere (i.e., the right hemisphere) and the linear rising edge after normalization was fitted into a line with its slope proportional to blood velocity as proved in previous publications. 22,58 By such analysis two slope values were obtained for each mouse, one derived from the control right cerebral hemisphere, and the other derived from the surgerized left cerebral hemisphere. Then the slope derived from the left hemisphere was normalized against that from right hemisphere to obtain the relative perfusion in the surgerized brain tissue to reveal the degree of occlusion of blood perfusion:…”

Section: Nir Fluorescence Imaging Of Phantom and Mouse Brain In Diffementioning

confidence: 99%

Through-skull fluorescence imaging of the brain in a new near-infrared window

et al. 2014

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To date, brain imaging has largely relied on X-ray computed tomography and magnetic resonance angiography with limited spatial resolution and long scanning times. Fluorescence-based brain imaging in the visible and traditional near-infrared regions (400–900 nm) is an alternative but currently requires craniotomy, cranial windows and skull thinning techniques, and the penetration depth is limited to 1–2 mm due to light scattering. Here, we report through-scalp and through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy utilizing the intrinsic photoluminescence of single-walled carbon nanotubes in the 1.3–1.4 micrometre near-infrared window. Reduced photon scattering in this spectral region allows fluorescence imaging reaching a depth of >2 mm in mouse brain with sub-10 micrometre resolution. An imaging rate of ~5.3 frames/s allows for dynamic recording of blood perfusion in the cerebral vessels with sufficient temporal resolution, providing real-time assessment of blood flow anomaly in a mouse middle cerebral artery occlusion stroke model.

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Section: Nir Fluorescence Imaging Of Phantom and Mouse Brain In Diffementioning

confidence: 99%

Through-skull fluorescence imaging of the brain in a new near-infrared window

et al. 2014

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“…Limited studies have applied ICG fluorescence angiography to patients with PAD. Zimmermann and colleagues 82 demonstrated ICG angiography correlated with the degree of vascular collateralization in the lower extremities of patients with PAD. This technique may also allow for real-time flow assessment in peripheral bypass surgery.…”

Section: Icg Fluorescence Angiographymentioning

confidence: 98%

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association

Misra¹,

Shishehbor²,

Takahashi³

et al. 2019

Circulation

103

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There are >12 million patients with peripheral artery disease in the United States. The most severe form of peripheral artery disease is critical limb ischemia (CLI). The diagnosis and management of CLI is often challenging. Ethnic differences in comorbidities and presentation of CLI exist. Compared with white patients, black and Hispanic patients have higher prevalence rates of diabetes mellitus and chronic renal disease and are more likely to present with gangrene, whereas white patients are more likely to present with ulcers and rest pain. A thorough evaluation of limb perfusion is important in the diagnosis of CLI because it can not only enable timely diagnosis but also reduce unnecessary invasive procedures in patients with adequate blood flow or among those with other causes for ulcers, including venous, neuropathic, or pressure changes. This scientific statement discusses the current tests and technologies for noninvasive assessment of limb perfusion, including the ankle-brachial index, toe-brachial index, and other perfusion technologies. In addition, limitations of the current technologies along with opportunities for improvement, research, and reducing disparities in health care for patients with CLI are discussed.

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“…A receiver operating characteristic curve analysis for the perfusion index revealed a positive LR of 6.00 and a negative LR of 0.00 with an area under the curve of 0.949 to discriminate critical and non-critical PAD. 53…”

Section: Indocyanine Green Angiographymentioning

confidence: 99%

Assessing chronic wound perfusion in the lower extremity: current and emerging approaches

Woo

Brandys²,

Marin³

2015

CWCMR

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Current evidence suggests that vascular and wound bed perfusion assessment should be integral to the care of people with chronic wounds in the lower extremities. Peripheral artery diseases can be insidious, with many affected individuals unaware of circulation issues and failing to seek medical help until they develop foot ulcers, gangrene, and other related complications. Measuring tissue perfusion is a useful diagnostic marker for chronic wounds and may help determine a wound's potential for healing. A complete patient history and physical examination is imperative to help determine the correct diagnosis of lower extremity ulcers. This article aims to discuss current and emerging wound perfusion assessment techniques, including ankle-brachial index, toe-brachial index, transcutaneous oxygen pressure, near-infrared spectroscopy, digital subtraction angiography, magnetic resonance angiography, computed tomographic angiography, and indocyanine green angiography.

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The determination of tissue perfusion and collateralization in peripheral arterial disease with indocyanine green fluorescence angiography

Cited by 27 publications

References 0 publications

Through-skull fluorescence imaging of the brain in a new near-infrared window

Through-skull fluorescence imaging of the brain in a new near-infrared window

Perfusion Assessment in Critical Limb Ischemia: Principles for Understanding and the Development of Evidence and Evaluation of Devices: A Scientific Statement From the American Heart Association

Assessing chronic wound perfusion in the lower extremity: current and emerging approaches

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