The detoxifying effect of Polygonum equisetiforme extracts against dichlorvos (DDVP)-induced oxidative stress and neurotoxicity in the commercial clam Ruditapes decussatus

Ayari, Tahani El; Mhadhbi, Lazhar; Debara, Nadia; Znati, Marwa; Dab, Houcine

doi:10.1007/s11356-019-07554-0

Cited by 10 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The greatest toxic effects of DDVP were observed at 0.25 mg/L, which caused significant changes of the several biochemical markers analyzed. This concentration was then selected by authors to test the protective effects of Polygonum equisetiforme extracts against the toxic effects of DDVP [ 104 ]. Even the exposure of mussel ( Mytilus edulis ) to DDVP (concentration gradient of 1–10,000 μg/L) for 24 h resulted in reduced gill AChE activity in a dose-dependent manner, while a persistent inhibition of AChE activity was caused by repeated exposures to DDVP.…”

Section: Marine Pollutants: Pesticidesmentioning

confidence: 99%

Neurotoxicity in Marine Invertebrates: An Update

Deidda

Russo

Bonaventura

et al. 2021

Biology

View full text Add to dashboard Cite

Invertebrates represent about 95% of existing species, and most of them belong to aquatic ecosystems. Marine invertebrates are found at intermediate levels of the food chain and, therefore, they play a central role in the biodiversity of ecosystems. Furthermore, these organisms have a short life cycle, easy laboratory manipulation, and high sensitivity to marine pollution and, therefore, they are considered to be optimal bioindicators for assessing detrimental chemical agents that are related to the marine environment and with potential toxicity to human health, including neurotoxicity. In general, albeit simple, the nervous system of marine invertebrates is composed of neuronal and glial cells, and it exhibits biochemical and functional similarities with the vertebrate nervous system, including humans. In recent decades, new genetic and transcriptomic technologies have made the identification of many neural genes and transcription factors homologous to those in humans possible. Neuroinflammation, oxidative stress, and altered levels of neurotransmitters are some of the aspects of neurotoxic effects that can also occur in marine invertebrate organisms. The purpose of this review is to provide an overview of major marine pollutants, such as heavy metals, pesticides, and micro and nano-plastics, with a focus on their neurotoxic effects in marine invertebrate organisms. This review could be a stimulus to bio-research towards the use of invertebrate model systems other than traditional, ethically questionable, time-consuming, and highly expensive mammalian models.

show abstract

Section: Marine Pollutants: Pesticidesmentioning

confidence: 99%

Neurotoxicity in Marine Invertebrates: An Update

Deidda

Russo

Bonaventura

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…According to the recently published research of El Ayari et al (2020) [194], the detoxifying effect of Polygonum equisetiforme extracts against dichlorvos induced oxidative stress and neurotoxicity in the commercial clam Ruditapes decussatus. Acquired results showed that even at the lower tested exposure level (0.05 mg L −1 ) and exposure for two days oxidative stress was induced which resulted in the reduction of AChE activity, whereas the greatest toxic effects were observed at 0.25 mg L −1 when significant changes of the several biochemical markers analyzed were reported to be caused [194].…”

Section: Natural Communities Of Marine Microphytobenthosmentioning

confidence: 99%

Potential Effects of Persistent Organic Contaminants on Marine Biota: A Review on Recent Research

Vagi

Petsas

Kostopoulou

2021

Water

View full text Add to dashboard Cite

Synthetic organic compounds belonging to different chemical classes and possessing diverse physicochemical properties are frequently present in marine environments. Microplastics, pharmaceuticals, pesticides, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are contained in the list of persistent organic pollutants (POPs) that have been detected in the global marine system. Numerous ecotoxicological studies have revealed the direct and indirect effects of anthropogenic toxicants on marine biota. The present review presents the research that has been conducted during the period from 1 January 2016 to 30 June2021 concerning the lethal and sub-lethal impacts of selected organic-synthetic stressors on different plant and animal marine species, and summarizes the observed or predicted individual and combined effects after exposure to chemical mixtures of such contaminants. Future research needs dependent on the knowledge gaps that remain in the bibliography are also highlighted.

show abstract

“…It has been well-established that OPPs cause alterations in brain function that may contribute to various neurological disorders. Several neurotransmitter systems, particularly the cholinergic system, have been implicated in developing memory impairment and cognitive deficits upon exposure to OPPs. − Additionally, recent studies revealed that OPPs can induce serotonergic system disturbances and mood disorders. , OPPs have high stability, and their half-life ranges from more than 2 days to several weeks . Therefore, these pesticide residues remain in soil, food, and water and affect human health .…”

Section: Introductionmentioning

confidence: 99%

Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice

Ommati,

Nozhat,

Sabouri

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Chlorpyrifos (CPF), dichlorvos (DDV), and cypermethrin (CP), as commonly used pesticides, have been implicated in inducing neuropsychiatric disorders, such as anxiety, depression-like behaviors, and locomotor activity impairment. However, the exact molecular mechanisms of these adverse effects, particularly in both sexes and their next-generation effects, remain unclear. In this study, we conducted behavioral analysis, along with cellular assays (monodansylcadaverine staining) and molecular investigations (qRT-PCR and western blotting of mTOR, P62, and Beclin-1) to clear the potential role of autophagy in pesticideinduced behavioral alterations. For this purpose, 42 adult female and 21 male inbred ICR mice (F0) were distributed into seven groups. Maternal mice (F0) and 112 F1 offspring were exposed to 0.5 and 1 ppm of CPF, DDV, and CP through drinking water. F1 male and female animals were studied to assess the sex-specific effects of pesticides on brain tissue. Our findings revealed pronounced anxiogenic effects and impaired locomotor activity in mice. F1 males exposed to CPF (1 ppm) exhibited significantly elevated depression-like behaviors compared to other groups. Moreover, pesticide exposure reduced mTOR and P62 levels, while enhancing the Beclin-1 gene and protein expression. These changes in autophagy signaling pathways, coupled with oxidative and neurogenic damage in the cerebral cortex and hippocampus, potentially contribute to heightened locomotor activity, anxiety, and depression-like behaviors following pesticide exposure. This study underscores the substantial impact of pesticides on both physiological and behavioral aspects, emphasizing the necessity for comprehensive assessments and regulatory considerations for pesticide use. Additionally, the identification of sex-specific responses presents a crucial dimension for pharmaceutical sciences, highlighting the need for tailored therapeutic interventions and further research in this field.

show abstract

The detoxifying effect of Polygonum equisetiforme extracts against dichlorvos (DDVP)-induced oxidative stress and neurotoxicity in the commercial clam Ruditapes decussatus

Cited by 10 publications

References 50 publications

Neurotoxicity in Marine Invertebrates: An Update

Neurotoxicity in Marine Invertebrates: An Update

Potential Effects of Persistent Organic Contaminants on Marine Biota: A Review on Recent Research

Pesticide-Induced Alterations in Locomotor Activity, Anxiety, and Depression-like Behavior Are Mediated through Oxidative Stress-Related Autophagy: A Persistent Developmental Study in Mice

Contact Info

Product

Resources

About