2012
DOI: 10.4161/auto.19381
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The deubiquitinating enzyme USP36 controls selective autophagy activation by ubiquitinated proteins

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Cited by 67 publications
(52 citation statements)
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“…Immunofluorescence microscopy of S2 cells and dissected fat body were performed as described by Bergeret et al [15] and Taillebourg et al [31], respectively. …”
Section: Methodsmentioning
confidence: 99%
“…Immunofluorescence microscopy of S2 cells and dissected fat body were performed as described by Bergeret et al [15] and Taillebourg et al [31], respectively. …”
Section: Methodsmentioning
confidence: 99%
“…Interestingly, this enzyme was previously shown by Richardson et al to positively control cell growth by stabilizing rRNA production and ribosome biogenesis (38). Moreover, knockdown of both yeast and fly USP36 homologs was shown to result in an inhibition of cell growth (38,39). Although further biological validation is required, in light of our model system, USP36 can potentially provide a novel link between deubiquitination and growth arrest in OIS.…”
Section: Resultsmentioning
confidence: 62%
“…dUsp36 hemocyte-specific knockdown was achieved by expressing a double-stranded RNA (dsRNA) targeting dUsp36 in hemocytes using the driver line hml-Gal4 [28]. The efficiency and specificity of the dsRNA construct used in this study have already been thoroughly characterized [26]. We observed that, with the three different doses of L. monocytogenes used for infection (10, 100 or 1,000 CFUs), flies with dUsp36 -depleted hemocytes ( hml>dUsp36-IR ) died significantly faster than control flies ( hml/+ ; fig.…”
Section: Resultsmentioning
confidence: 99%
“…Scrawny or Emperor's thumb ) deubiquitinating enzyme acts as a negative regulator of the imd pathway by deubiquitinating the IMD protein [25]. We have also shown that dUsp36 controls cell growth and selective autophagy activation by ubiquitinated proteins [26]. Interestingly, a genome-wide RNAi-based screen conducted to identify host processes that contribute to L. monocytogenes pathogenesis identified dUsp36 (referred to as CG5505 ) as part of a group of genes whose knockdown led to enhanced L. monocytogenes intracellular growth [27].…”
Section: Introductionmentioning
confidence: 99%