The developing infant gut microbiome: A strain-level view

Enav, Hagay; Bäckhed, Fredrik; Ley, Ruth E.

doi:10.1016/j.chom.2022.04.009

Cited by 60 publications

(36 citation statements)

References 86 publications

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“…These impacts of excess GWG were also associated with a shift in microbiota beta-diversity at 6 months of age in infants of multiparous—but not primiparous—participants. These same infants also had a decrease in Bacteroides and increase in Bifidobacterium reflecting similar shifts in the maternal gut microbiota consistent with the high rates of vertical transmission previously found for these genera 61 . Therefore, health behaviours during pregnancy and the postpartum/intrapartum interval should be supported not only for maternal health but also infant microbiotal health.…”

Section: Discussionsupporting

confidence: 81%

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Kennedy

Plagemann

Sommer

et al. 2022

Preprint

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Shifts in the gut microbiome have been implicated in mediating maternal metabolic adaptations to pregnancy. We investigated the impact of pre-pregnancy BMI (pBMI) and gestational weight gain (GWG) on pregnancy-associated remodeling of the maternal gut microbiome and infant colonization, and whether previous pregnancies modulated observed associations. We found that the gut microbiota of participants with higher pBMI changed less over the course of pregnancy in primiparous, but not multiparous participants This suggests that previous pregnancies may have persistent impacts on maternal microbiotal adaptations to pregnancy. This ecological memory appears to be passed to the next generation, as parity impacted infant microbial composition of first-pass meconium and modulated the impact of maternal GWG on the infant gut microbiome. This work supports a role for the gut microbiome in maternal adaptations to pregnancy and highlights parity as a key consideration for studies of the microbiome in pregnancy and infants.

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Section: Discussionsupporting

confidence: 81%

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Kennedy

Plagemann

Sommer

et al. 2022

Preprint

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“…Within these cosmopolitan species, different strains can dominate in different populations (4)(5)(6)(7). Strain variation can arise in several ways, from the uptake of new strains to their in situ evolution (8). When strains and their hosts evolve in parallel, they codiversify, and as a result, their phylogenies are congruent.…”

mentioning

confidence: 99%

“…S2). For mother-child pairs, strain sharing is often interpreted as vertical transmission, but acquisition of strains from a shared environment cannot be excluded ( 8 ). Indeed, our data also support strain sharing between community members: Within sampling locations in Gabon and Vietnam, we observed instances of the same strains in the microbiomes of mothers and unrelated children (fig.…”

mentioning

confidence: 99%

Codiversification of gut microbiota with humans

Suzuki

Fitzstevens

Schmidt

et al. 2022

Science

107

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The gut microbiomes of human populations worldwide have many core microbial species in common. However, within a species, some strains can show remarkable population specificity. The question is whether such specificity arises from a shared evolutionary history (codiversification) between humans and their microbes. To test for codiversification of host and microbiota, we analyzed paired gut metagenomes and human genomes for 1225 individuals in Europe, Asia, and Africa, including mothers and their children. Between and within countries, a parallel evolutionary history was evident for humans and their gut microbes. Moreover, species displaying the strongest codiversification independently evolved traits characteristic of host dependency, including reduced genomes and oxygen and temperature sensitivity. These findings all point to the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease phenotypes.

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“…Although the gut microbiota are easily agitated during the initial years of postnatal development, consistent microbiota are observed over time. Genetic and environmental factors, including food, antibiotics, and exposure to other microbes, control the fetus’s early gut microbiota composition [ 15 ]. Thus, a healthy adult gut microbiota is highly adapted to the host and the host’s environment.…”

Section: Gut Microbiota and Metabolic Factorsmentioning

confidence: 99%

The Molecular Gut-Brain Axis in Early Brain Development

Muhammad

Fan

Wang

et al. 2022

IJMS

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Millions of nerves, immune factors, and hormones in the circulatory system connect the gut and the brain. In bidirectional communication, the gut microbiota play a crucial role in the gut-brain axis (GBA), wherein microbial metabolites of the gut microbiota regulate intestinal homeostasis, thereby influencing brain activity. Dynamic changes are observed in gut microbiota as well as during brain development. Altering the gut microbiota could serve as a therapeutic target for treating abnormalities associated with brain development. Neurophysiological development and immune regulatory disorders are affected by changes that occur in gut microbiota composition and function. The molecular aspects relevant to the GBA could help develop targeted therapies for neurodevelopmental diseases. Herein, we review the findings of recent studies on the role of the GBA in its underlying molecular mechanisms in the early stages of brain development. Furthermore, we discuss the bidirectional regulation of gut microbiota from mother to infant and the potential signaling pathways and roles of posttranscriptional modifications in brain functions. Our review summarizes the role of molecular GBA in early brain development and related disorders, providing cues for novel therapeutic targets.

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The developing infant gut microbiome: A strain-level view

Cited by 60 publications

References 86 publications

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Parity modulates impact of BMI and Gestational Weight Gain on gut microbiota in human pregnancy

Codiversification of gut microbiota with humans

The Molecular Gut-Brain Axis in Early Brain Development

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