The developing world of DOHaD

Abstract

Since its debut in a ground-breaking report by Barker and Osmond in 1986, the concept of the Developmental Origins of Health and Disease (DOHaD) has been further developed in several aspects. Its methodology and conclusions relating to proposed origins and outcomes of early life events have been developing and spreading internationally. Indeed, the DOHaD concept now seems to have influenced many fields of research. This article aims to briefly review why the DOHaD concept is important in biomedical science, how it has developed, is currently developing, and how it should develop in future.

DOHaD (Barker-hipotézis): egy betegségorientált, korszakalkotó, brit eredetű teória, magyar gyökerekkel

“…Mindkettő korunk terméke, amennyiben megváltoztattuk a kritikus periódusokban a táplálkozási szokásokat, illetve tömegesen olyan, ember teremtette anyagokkal hoztuk érintkezésbe a fejlődő magzatot (és serdülőt), melyek strukturálisan és/vagy funkcionálisan utánoznak bizonyos, fiziológiásan jelen lévő molekulákat, ezek receptoraikhoz kötődnek, ezáltal hibás információkat továbbítanak, ami a fejlődési program tartós megváltozásához vezet. Míg a DOHaD-teória a kórosnak tekinthető magzati állapotokra helyezi a hangsúlyt a felnőttkori betegség okaként [37], addig a hormonális imprinting koncepciója a kémiai faktorokra, melyek a környezetünkben, ebből következőleg az anya vagy a magzat, serdülő stb. szervezetében feldúsuló idegen molekulákra (endokrin disruptorokra) [38].…”

How to make the first thousand days count

“…The biological processes described in the developmental programming hypothesis are themselves determined by social and environmental exposures . Epigenetics and humanomics elucidate the importance of these exposures to the mother, the foetus and the infant and in the case of epigenetics to the heritability across generations from grandmother to grandchild.…”

Proceedings of the 5th annual symposium of the German Society for Paleo Nutrition held in 2017

“…the evolution of the individual being versus the first evolution of the human species). Within the developmental origins of health and disease (DOHaD) paradigm, studies are increasingly identifying links between maternal morbidity during pregnancy and disease later in life for offspring [55]. Nutrient restriction, metabolic disorders during gestation, such as diabetes or obesity, and maternal immune activation provoked by infection have been linked to adverse health outcomes for offspring later in life.…”