The Development and Anatomy of the Mesentery

The implication of mesenteric functions and the biological effects of nanomaterials on the mesentery

“…The intricate connective networks between the mesentery and the intestine are both biological barriers and important conduits for the entry of exogenous substances/particles through the oral route. 31 Upon entering the intestine, nanoparticles may penetrate the mesentery and alter its structure or function. For instance, these particles may traverse cellular bypass pathways or active cellular transport pathways and interact with adipose tissue and lymphocytes, potentially obstructing lymphatic or blood vessels, leading to the formation of a third immune organ, and thereby altering the mesenteric immune microenvironment.…”

“…For instance, the division of lymphatic fibers and blood vessels from the central part of the mesentery strengthens the link between the mesentery and the connected organs. 31 The mesenteric lymph nodes in the mouse mesentery are located near the colon and surrounded by adipose tissue, connecting to the small intestine. This arrangement allows for the independent function of the intestine's immune system (Fig.…”